Parathyroid hormone variants
AssigneeShire-NPS Pharmaceuticals, Inc.
InventorsClark Pan, Angela Norton, Kevin Holmes, David Bruce Lloyd, Bryan James Goodwin, Rongxin Shi, Sujit Jain, Chuan Shen
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Abstract
The invention relates to parathyroid hormone (PTH) variants and pharmaceutical compositions comprising same. The invention further relates to PTH compositions with improved serum half-life and peak-trough ratios, and methods of controlling serum calcium levels with the PTH variants and compositions of the invention. The invention further relates to methods of treating hypoparathyroidism and/or hypocalcemia due to hypoparathyroidism with the PTH variants and compositions of the invention.
Claims5
A parathyroid hormone (PTH)-Fc fusion protein, wherein the PTH-Fc fusion protein is PTH-66 having the amino acid sequence of SEQ ID NO:
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Dependencies are inferred from the claim text.