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US 11,634,460 B2Granted
Non-neuronal snare-cleaving botulinum neurotoxins
AssigneeIpsen Biopharm Ltd.
InventorsThomas Binz, Stefan Sikorra
Life of this patent
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Abstract
The present invention provides a modified botulinum neurotoxin A (BoNT/A) L-chain protease that demonstrates enhanced cleaveage of human SNAP-23 (hSNAP-23) relative to unmodified (wild-type) BoNT/A L-chain protease, together with the use thereof for cleaving hSNAP-23.
Claims18
A modified botulinum neurotoxin A (BoNT/A) L-chain protease comprising an amino acid sequence that has at least 95% sequence identity to SEQ ID NO:
- 1 and
- tyrosine at the position corresponding to residue position 148 of SEQ ID NO:
- 1.
Dependencies are inferred from the claim text.