Peptides and compositions for use in cosmetics and medicine
AssigneeLipotrue, S.L.
InventorsAriadna Grau-Campistany, Silvia Pastor, Patricia Carulla, Juan Carlos Escudero, Julia A. Boras, Isabel Devesa Giner, Gregorio Fernandez Ballester
Life of this patent
Estimating the term…
Abstract
The present invention relates to a family of peptides which are able to interfere in the formation of complex Munc18-Syntaxin-1 and, hence, are useful in the prevention and/or treatment of neuronal exocytosis and/or muscle contractility disorders; and to prevent, reduce and/or eliminate skin aging and/or expression signs.
Claims24
A method of reducing skin aging and/or facial expression lines in a subject in need thereof comprising applying to the subject in need thereof a peptide or cosmetic composition comprising said peptide, wherein the peptide has a sequence in accordance with formula (I):
- R1-AA1-AA2-AA3-AA4-AA5-AA6-R2 (I)
- cosmetically and pharmaceutically acceptable isomers, salts, solvates and/or derivatives and mixtures thereof, wherein:
- AA1 is His;
- AA2 is selected from the group consisting of Gly, Ala, Val, Leu, Met and Ile;
- AA3 is selected from the group consisting of Gly, Ala, Val, Leu, Met and Ile;
- AA4 is selected from the group consisting of Lys, Arg, His, Asp and Glu;
- AA5 is selected from the group consisting of Met, Phe, Tyr and Trp;
- and
- AA6 is Trp;
- R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO— wherein R5 is selected from the group formed by substituted or unsubstituted C1-C24 alkyl radical, substituted or unsubstituted C2-C24 alkenyl, substituted or unsubstituted C2-C24 alkynyl, substituted or unsubstituted C3-C24 cycloalkyl, substituted or unsubstituted C5-C24 cycloalkenyl, substituted or unsubstituted C8-C24 cycloalkynyl, substituted or unsubstituted C6-C30 aryl, substituted or unsubstituted C7-C24 aralkyl, substituted or unsubstituted heterocyclyl ring of 3 to 10 members, and substituted or unsubstituted heteroarylalkyl of 2 to 24 carbon atoms and 1 to 3 atoms other than carbon and an alkyl chain of 1 to 6 carbon atoms;
- and
- R2 is selected from the group consisting of H, —NR3R4—, —OR3 and —SR3, wherein R3 and R4 are independently selected from H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl (R1-SEQ ID NO:
- 15-R2),
- wherein the peptide interferes in the Munc18-Syntaxin-1 complex interaction and competes with SEQ ID NO:
- 3 and/or SEQ ID NO:
- 4, acceptable isomers, salts, solvates and/or derivatives and/or mixtures thereof.
A method of reducing skin aging and/or facial expression lines in a subject in need thereof comprising applying to the subject in need thereof a peptide or cosmetic composition comprising said peptide, the peptide having a sequence in accordance with formula (II) R1-AA1-AA2-AA3-AA4-R2, wherein the peptide of formula (II) is:
- (Ac-SEQ ID NO:
- 10-NH2)
- Ac-Arg-Arg-Arg-Phe-NH2;
- and/or
- (Ac-SEQ ID NO:
- 11-NH2)
- Ac-Arg-Met-Arg-Phe-NH2.
A method of reducing skin aging and/or facial expression lines in a subject in need thereof comprising applying to the subject in need thereof a peptide or cosmetic composition comprising said peptide, wherein the peptide has a sequence in accordance with formula (II) R1-AA1-AA2-AA3-AA4-R2, wherein the peptide of formula (II) is R1-Arg-Arg-Arg-Phe-R2 (R1-SEQ ID NO:
- 10-R2);
- or R1-Arg-Met-Arg-Phe-R2 (R1-SEQ ID NO:
- 11-R2) and wherein R1 is selected from the group consisting of H, substituted or unsubstituted non-cyclic aliphatic, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, substituted or unsubstituted aralkyl and R5—CO— wherein R5 is selected from the group formed by substituted or unsubstituted C1-C24 alkyl radical, substituted or unsubstituted C2-C24 alkenyl, substituted or unsubstituted C2-C24 alkynyl, substituted or unsubstituted C3-C24 cycloalkyl, substituted or unsubstituted Cs-C24 cycloalkenyl, substituted or unsubstituted Cs-C24 cycloalkynyl, substituted or unsubstituted C6-C3O aryl, substituted or unsubstituted C-C24 aralkyl, substituted or unsubstituted heterocyclyl ring of 3 to 10 members, and substituted or unsubstituted heteroarylalkyl of 2 to 24 carbon atoms and 1 to 3 atoms other than carbon and an alkyl chain of 1 to 6 carbon atoms;
- and
- R2 is selected from the group consisting of H, —NR3R4—, —OR3 and —SR3, wherein R3 and R4 are independently selected from H, substituted or unsubstituted non-cyclic aliphatic group, substituted or unsubstituted alicyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted aryl, and substituted or unsubstituted aralkyl (R1-SEQ ID NO:
- 15-R2).
Dependencies are inferred from the claim text.