Methods of reducing level of one or more impurities in a sample during protein purification
AssigneeEMD Millipore Corporation
InventorsNanying Bian, Christopher Gillespie, Matthew T. Stone, Mikhail Kozlov, Jie Chen, Martin Siwak
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Abstract
The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely affecting the yield of the desired protein product.
Claims10
A purification process for purifying a protein of interest from a Protein A eluate comprising a protein of interest and impurities, the process comprising contacting the eluate with a carbonaceous material and one or more matrices selected from anion exchange media, cation exchange media, and virus filtration media.
Dependencies are inferred from the claim text.