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AssigneeThe General Hospital Corporation
InventorsHarald C. Ott, Xi Ren, Jordan P. Bloom, Taufiek Konrad Rajab
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The present application provides methods of functionalizing an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal or by culturing an organ or tissue in a bioreactor containing such nutrient. The present application also provides methods of selectively functionalizing extracellular matrix (ECM) of an organ or tissue of a mammal by administering a nutrient (e.g., peracetylated N-azido galactosamine Ac4GalNAz) to the mammal. In some aspects, the present application provides a decellularized scaffold of a mammalian organ or tissue comprising an extracellular matrix, wherein the extracellular matrix of the decellularized scaffold is functionalized with a chemical group that is reactive in a bioorthogonal chemical reaction, such as an azide chemical group. The present application also provides biological prosthetic mesh and mammalian organs and tissues for transplantation prepared according to the methods of the application.
A method of preparing a decellularized scaffold of an organ or tissue of a mammal comprising an extracellular matrix functionalized with a chemical group that is reactive in a biorthogonal chemical reaction, the method comprising:
Dependencies are inferred from the claim text.