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US 11,634,437 B2Granted
Fluorescent compounds specific for pluripotent stem cells and reprogramming-ready cells and methods of using the same
AssigneeAgency for Science, Technology and Research
InventorsSandhya Sriram, Shigeki Sugii, Young Tae Chang, Nam-Young Kang
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Abstract
The present invention provides fluorescent compounds of formula (I) as disclosed herein or pharmaceutically acceptable salts thereof. Further provided are uses of said fluorescent compounds in methods of determining, in a sample, the presence and/or amount of pluripotent stem cells or cells undergoing reprogramming to become induced pluripotent stem cells.
Claims2
A labelled cell formed from a cell and a fluorescent compound of formula (I) or a pharmaceutically acceptable salt thereof
- wherein:
- R1, R4, R5, R8, R9 and R10 are each independently selected from the group consisting of H and methyl;
- R2, R3, R6 and R7 are each methyl;
- R11 is (CH2)2—N(CH3)2;
- m and n are each independently 0, 1, or 2;
- p is 0, 1, 2, or 3,
- q is 1, 2, 3, or 4, with the proviso that p+q≤4;
- and
- means that the respective bond can be a single or double bond and, if it is a single bond, the additional valencies are hydrogen, and
- wherein the cell is a cell undergoing reprogramming to become an induced pluripotent stem cell.
7 more elements
Dependencies are inferred from the claim text.