Pyridine lactam compounds and methods of use thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• R1 is selected from the group consisting of hydrogen, C1-C4 alkyl, and CD3;
• each R1 is independently selected from the group consisting of hydrogen, deutero, halogen, cyano, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 thioalkyl, cyano, phenyl, benzyl, CH2—(C1-C6 cycloalkyl), CH2CH2—(C3-C6 cycloalkyl), C4-C6 heterocyclyl, C5-C6 heteroaryl, CH2—(C4-C6 heterocyclyl), CH2CH2—(C4-C6 heterocyclyl), CH2—(C5-C6 heteroaryl), and CH2CH2—(C5-C6 heteroaryl);
• n is 0, 1 or 2;
• X is selected from the group consisting of O, S, S(O), SO2, CH2, CH(CH3), C(CH)2, CF2 and CHCF3;
• Y is N;
• the A ring and the B ring are fused to form a polycyclic ring system, wherein:
• the A ring is either:
• (i) a 5 membered heteroaromatic ring having as its only heteroatoms, either (a) two or three nitrogen atoms, (b) one nitrogen atom and one oxygen atom, or (c) one nitrogen atom and one sulfur atom;
• or
• (ii) a 6 membered heteroaromatic ring having as its only heteroatoms 1 to 3 nitrogen atoms;
• wherein the A ring is optionally substituted at a carbon atom by one substituent selected from the group consisting of fluoro, chloro, methyl, and trifluoromethyl;
• and
• the B ring is a 5 to 7 membered carbocyclic ring, a 5 to 7 membered heterocyclic ring, or a 5 to 6 membered heteroaryl ring, wherein the heterocyclic or heteroaryl ring has 1 to 3 heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur;
• p is 1 or 2, and q is 0 or 1;
• or p is 0, and q is 1;
• each RB1 is independently selected from the group consisting of halogen, deutero, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 thioalkyl, C1-C6 alkyl-N(RN)2, and cyano;
• wherein two C1-C6 alkyl substituents may together form a bridged or spirocyclic ring;
• and wherein if a nitrogen atom in the B ring is substituted, the substituent is not halogen, cyano, or a C1-C6 alkoxy, C1-C6 haloalkoxy or C1-C6 thioalkyl having an oxygen or sulfur atom directly bonded to the nitrogen atom;
• RB2 is selected from the group consisting of C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, C3-C6 alkoxy, C1-C6 haloalkoxy, C1-C6 thioalkyl, C1-C6 alkyl-N(RN)2, phenyl, benzyl, CH2—(C3-C6 cycloalkyl), CH2CH2—(C3-C6 cycloalkyl), CH2-(4 to 6 membered heterocyclyl), CH2CH2-(4 to 6 membered heterocyclyl), 5 to 6 membered heteroaryl, and CH2-(5 to 6 membered heteroaryl);
• wherein when RB2 is phenyl or benzyl the phenyl ring is optionally substituted by 1 to 3 substituents selected from the group consisting of halogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxy, C1-C4 haloalkoxy, and cyano;
• R7a and R7b are each independently selected from the group consisting of H, halogen, and C1-C6 alkyl;
• or R7a and R7b may together with the carbon atom to which they are both attached form cyclopropyl;
• and
• each RN is independently selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, and C1-C6 haloalkyl;
• or two RN together with the nitrogen atom to which they are both attached form a 4-6 membered heterocyclic ring;
• provided that if n is 2, only one R2 may be phenyl, benzyl, CH2—(C3-C6 cycloalkyl), CH2CH2—(C3-C6 cycloalkyl), C4-C6 heterocyclyl, C5-C6 heteroaryl, CH2—(C4-C6 heterocyclyl), CH2CH2—(C4-C6 heterocyclyl), CH2—(C5-C6 heteroaryl), or CH2CH2—(C5-C6 heteroaryl).