Amino acid compounds and methods of use

A compound of formula (I-A):

• or a salt thereof, wherein:
• R1 is C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl, —OR2 or —NR3aR3b, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R1 are independently optionally substituted by R10;
• R2 is C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R2 are independently optionally substituted by R10;
• R3a and R3b are independently hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R3a and R3b are independently optionally substituted by R10;
• or R3a and R3b are taken together with the nitrogen to which they are attached to form a 4- to 8-membered heterocyclyl optionally substituted by R10;
• n is 1 or 2;
• s is 0, 1 or 2, wherein the sum of n and s is 1, 2 or 3;
• the ring defined by is present or absent;
• m is 0 to 6;
• each R5, where present, is independently C1-C6 alkyl, C3-C6 cycloalkyl, halogen, —CN, —OR5a, —C(O)OR5a, —NR5aC(O)R5b;
• —NR5cR5d, —C(O)NR5cR5d, —SO2R5e, or —SO2NR5cR5d, wherein the C1-C6 alkyl and C3-C6 cycloalkyl are independently optionally substituted by R10;
• each R5a and R5b is independently hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R5a and R5b are independently optionally substituted by R10;
• each R5c and R5d is independently hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R5c and R5d are independently optionally substituted by R10;
• or R5c and R5d are taken together with the nitrogen to which they are attached to form a 4- to 8-membered heterocyclyl optionally substituted by R10;
• each R5e is independently C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, or 3- to 12-membered heterocyclyl, wherein the C1-C6 alkyl, C3-C8 cycloalkyl, C6-C14 aryl, 5- to 10-membered heteroaryl, and 3- to 12-membered heterocyclyl of R5e are independently optionally substituted by R10;
• X is C1-C3 alkylene optionally substituted by R10, —N(R11)—C1-C3 alkylene optionally substituted by R10, —C1-C3 alkylene-N(R11)— optionally substituted by R10, —C1-C3 alkylene-N(R11)—C1-C3 alkylene- optionally substituted by R10, —O—C1-C3 alkylene optionally substituted by R10, —C1-C3 alkylene-O— optionally substituted by R10, —C1-C3 alkylene-O—C1-C3 alkylene- optionally substituted by R10;
• Y is C(Rya)(Ryb) or N(R11);
• each of Rya and Ryb is independently H, C1-C6 alkyl, C3-C6 cycloalkyl, halogen, —CN, —OR5a, —C(O)OR5a, —NR5aC(O)R5b;
• —NR5cR5d, —C(O)NR5cR5d, —SO2R5e, or —SO2NR5cR5d, wherein the C1-C6 alkyl and C3-C6 cycloalkyl are independently optionally substituted by R10;
• p is 0 to 2;
• q is 0 to 6;
• each R7, where present, is independently C1-C6 alkyl optionally substituted by halogen or —OH, C3-C6 cycloalkyl, halogen, —CN, —NO2, —OR7a, or —NR7bR7c;
• each R7a, R7b and R7c is independently hydrogen or C1-C3 alkyl;
• each R8, where present, is independently C1-C6 alkyl, C3-C6 cycloalkyl, halogen, oxo or —OR8a, wherein the C1-C6 alkyl and C3-C6 cycloalkyl are independently optionally substituted by R10;
• R8a is hydrogen or C1-C6 alkyl;
• each R9 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halogen, —CN, —OR11, —SR11, —NR12R13, —NO2, —C═NH(OR11), —C(O)R11, —OC(O)R11, —C(O)OR11, —C(O)NR12R13, —NR11C(O)R12, —NR11C(O)OR12, —NR11C(O)NR12R13, —S(O)R11, —S(O)2R11, —NR11S(O)R12, —NR11S(O)2R12, —S(O)NR12R13, —S(O)2NR12R13, —P(O)(OR12)(OR13), C3-C8 cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, wherein each R9 is independently optionally substituted by halogen, oxo, —OR14, —NR14R15, —C(O)R14, —CN, —S(O)R14, —S(O)2R14, —P(O)(OR14)(OR15), C3-C8 cycloalkyl, 3- to 12-membered heterocyclyl, 5- to 10-membered heteroaryl, C6-C14 aryl, or C1-C6 alkyl optionally substituted by oxo, —OH or halogen;
• each R10 is independently oxo or R9;
• R11 is independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl are independently optionally substituted by halogen, oxo, —CN, —OR16, —NR16R17, —P(O)(OR16)(OR17), or C1-C6 alkyl optionally substituted by halogen, —OH or oxo;
• R12 and R13 are each independently hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl or 3- to 6-membered heterocyclyl, wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, C6-C14 aryl, 5- to 6-membered heteroaryl and 3- to 6-membered heterocyclyl are independently optionally substituted by halogen, oxo, —CN, —OR16, —NR16R17 or C1-C6 alkyl optionally substituted by halogen, —OH or oxo;
• or R12 and R13 are taken together with the atom to which they attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo, —OR16, —NR16R17 or C1-C6 alkyl optionally substituted by halogen, oxo or —OH;
• R14 and R15 are each independently hydrogen, C1-C6 alkyl optionally substituted by halogen or oxo, C2-C6 alkenyl optionally substituted by halogen or oxo, or C2-C6 alkynyl optionally substituted by halogen or oxo;
• or R14 and R15 are taken together with the atom to which they are attached to form a 3- to 6-membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by halogen or oxo;
• and
• R16 and R17 are each independently hydrogen, C1-C6 alkyl optionally substituted by halogen or oxo, C2-C6 alkenyl optionally substituted by halogen or oxo, or C2-C6 alkynyl optionally substituted by halogen or oxo;
• or R16 and R17 are taken together with the atom to which they are attached to form a 3-6 membered heterocyclyl optionally substituted by halogen, oxo or C1-C6 alkyl optionally substituted by oxo or halogen.