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US 11,634,415 B2Granted
Derivatives of substituted morpholines and uses thereof
AssigneeSupernus Pharmaceuticals, Inc.
InventorJanak Khimchand Padia
Life of this patent
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Abstract
A compound of Formula I includes a stereoisomer thereof and/or a salt thereof; wherein R1 is a substituted alkane group, a heterocylic group, or a pyridine group; X is hydrogen, a halogen, an amino acid residue, a substituted amino acid residue, an alkyl group, or an ester. Such compounds may be used in pharmaceutical compositions and for the treatment of central nervous system (CNS) disorders:
Claims29
A compound of Formula I, a stereoisomer thereof, or a salt thereof:
- wherein:
- R1 is alkyl, heterocyclyl, or a pyridyl;
- R2 is alkyl, aryl, heteroaryl, or heterocyclyl;
- R3-R14 are each independently H, F, Cl, Br, I, CN, NO2, alkyl, aryl, heteroaryl, or heterocyclyl;
- and
- X is halogen, an amino acid residue with a hydrophobic side chain, or ester, wherein X may also be H only when R1 is pyridyl.
3 more elements
A compound of formula:
- wherein:
- R15 is H, alkyl, —C(O)OR17, or —C(O)R17, wherein R17 is H or alkyl;
- and
- R16 is H, alkyl, —C(O)OR17, or —C(O)R17, wherein R17 is H or alkyl.
1 more element
Dependencies are inferred from the claim text.