Treatment of cancer/inhibition of metastasis
AssigneeCelex Oncology Ltd.
InventorMustafa Djamgoz
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Abstract
Substances and methods are dislosed for reducing or preventing metastatic behaviour in VGSC expressing cancer by the effect of at least reducing the persistent part of the voltage gated sodium channel current without eliminating the transient part. Inhibition of metastatic cell behaviours such as detachability, lateral motility, transverse migration and invasiveness is demonstrated using the known drugs ranolazine and riluzole.
Claims7
A method for inhibiting metastatic and invasive growth of malignant cells in a cancer patient in need thereof, comprising administering an effective and pharmaceutically acceptable amount to the patient of an inhibitor of a voltage gated sodium channel (VGSC), wherein the effective and pharmaceutically acceptable amount is not lethal to the malignant cells, blocks the persistent part of the VGSC current, and does not block the transient part of the VGSC current, wherein the inhibitor of the VGSC is ranolazine.
Dependencies are inferred from the claim text.