Anatomic tissue-engineered osteochondral implant and method for fabrication thereof

A method for forming a prosthesis having a bone-like portion and a cartilage-like portion, the method comprising:

• additively manufacturing a first positive mold in accordance with at least a portion of a first three-dimensional model of at least a portion of a bone;
• forming a first negative mold from the first positive mold;
• creating the bone-like portion of the prosthesis within the first negative mold;
• additively manufacturing a second positive mold of the bone and a cartilage from a second three-dimensional model, wherein a portion of the second three-dimensional model corresponds to a portion of the first three-dimensional model;
• forming a second negative mold from the second positive mold;
• positioning the bone-like portion of the prosthesis in the second negative mold so that the second negative mold and the bone-like portion of the prosthesis cooperatively define a cartilage space;
• and
• filling the cartilage space with a material to form the cartilage-like portion of the prosthesis.