Immunosuppressive protein adsorption material and adsorption column

An adsorption material for an immunosuppressive protein, the adsorption material comprising:

• a water-insoluble carrier to which at least one nitrogen-containing compound is bound,
• wherein the nitrogen-containing compound is selected from a polyamine represented by any one of the following Formulas (1-1) to (1-6), and a secondary aliphatic amine represented by the following Formula (3),
• wherein a total content of amino groups on the water-insoluble carrier is more than 30 to 2400 μmol per 1 g of the adsorption material,
• wherein a proportion of the content of primary amino groups to the total content of amino groups (the content of primary amino groups/the total content of amino groups) is 0.20 or less;
• and
• a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g of the adsorption material:
• H2N—(CH2)p1—NH2 Formula (1-1)
• wherein in Formula (1-1), p1 is an integer from 2 to 4, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• H2N—(CH2)p1—NH—(CH2)p2—NH2 Formula (1-2)
• wherein in Formula (1-2), p1 and p2 are each independently an integer from 2 to 5, the hydrogen atom of the secondary amino group is optionally replaced with an alkyl group optionally having an amino group, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• H2N—(CH2)p1—NH—(CH2)p2—NH—(CH2)p3—NH2 Formula (1-3)
• wherein in Formula (1-3), p1, p2, and p3 are each independently an integer from 2 to 5, the hydrogen atoms of the secondary amino groups are optionally each independently replaced with an alkyl group optionally having an amino group, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• H2N—(CH2)p1—NH—(CH2)p2—NH—(CH2)p3—NH—(CH2)p4—NH2 Formula (1-4)
• wherein in Formula (1-4), p1, p2, p3, and p4 are each independently an integer from 2 to 5, the sum of p1, p2, p3, and p4 is 17 or less, the hydrogen atoms of the secondary amino groups are optionally each independently replaced with an alkyl group optionally having an amino group, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• H2N—(CH2)p1—NH—(CH2)p2—NH—(CH2)p3—NH—(CH2)p4—NH—(CH2)p5—NH2 Formula (1-5)
• wherein in Formula (1-5), p1, p2, p3, p4, and p5 are each independently an integer from 2 to 5, the sum of p1, p2, p3, p4 and p5 is 16 or less, the hydrogen atoms of the secondary amino groups are optionally each independently replaced with an alkyl group optionally having an amino group, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• H2N—(CH2)p1—NH—(CH2)p2—NH—(CH2)p3—NH—(CH2)p4—NH—(CH2)p5—NH—(CH2)p6—NH2 Formula (1-6)
• wherein in Formula (1-6), p1, p2, p3, p4, p5, and p6 are each independently an integer from 2 to 5, the sum of p1, p2, p3, p4, p5, and p6 is 15 or less, each of the hydrogen atoms of the secondary amino groups is optionally independently replaced with an alkyl group optionally having an amino group, and at least one of the hydrogen atoms of the primary amino groups at both ends is optionally replaced with an alkyl group;
• NHR6R7 Formula (3)
• wherein in Formula (3), R6 and R7 are each independently a saturated or unsaturated aliphatic hydrocarbon group having 1 to 12 carbon atoms.