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US 11,633,698 B2Granted
Method and apparatus for the filtration of biological solutions
AssigneeSpf Innovations, LLC
InventorsGaston de los Reyes, Leon Mir
Life of this patent
Estimating the term…
Abstract
A system, method and device are disclosed for bio-processing a feed stream and providing a constant output by operating a continuous single-pass tangential-flow process. The single-pass process provides high conversion concentration while operating at relatively low feed flow rates, and the process can also be used to provide constant output diafiltration.
Claims14
A filtration system comprising:
- a plurality of sections, each section having at least one channel providing at least one serial flow path, each section being in fluid communication with each adjacent section preceding it and being in fluid communication with each adjacent section that follows it;
- each of the at least one channel comprising a filtration membrane and having a length, a membrane area, a void volume, a specific membrane area expressed as a ratio of the membrane area to the void volume, and a dimensionless length expressed as a product of the channel length and the specific membrane area;
- wherein a dimensionless length of each respective section of the plurality of sections is defined as the sum of the dimensionless lengths of each channel in a longest serial flow path in the respective section and the dimensionless length of the system is the sum of the dimensionless lengths of the plurality of sections;
- wherein the dimensionless length of the system is greater than about 2,000 and the dimensionless length of at least one of the plurality of sections is less than about 6,000;
- and
- wherein at least one of the plurality of sections comprises one of:
- a spiral-wound cartridge;
- and
- a spiral-wound module.
6 more elements
A filtration system comprising:
- a plurality of sections, each stage having at least one channel providing at least one serial flow path, each stage being in fluid communication with each adjacent section preceding it and being in fluid communication with each adjacent section that follows it;
- each of the at least one channel comprising a filtration membrane and having a length, a membrane area, a void volume, a specific membrane area expressed as a ratio of the membrane area to the void volume, and a dimensionless length expressed as a product of the channel length and the specific membrane area;
- wherein a dimensionless length of each respective section of the plurality of sections is defined as the sum of the dimensionless lengths of each channel in a longest serial flow path in the section and the dimensionless length of the system is the sum of the dimensionless lengths of the plurality of sections;
- wherein the specific membrane area of the at least one channel in the plurality of channels in the plurality of sections is greater than about 40 cm−1;
- and
- wherein at least one of the plurality of sections comprises one of:
- a spiral-wound cartridge;
- and
- a spiral-wound module.
6 more elements
A method for filtering a liquid feed stream comprising:
- continuously supplying the liquid feed stream at a specific feed flow rate of less than about 200 lmh into a separation module having at least one channel having a specific membrane area greater than about 40 cm−1;
- wherein the at least one channel comprises a filtration membrane and having a length, a membrane area, a void volume and a specific membrane area expressed as a ratio of the membrane area to the void volume;
- wherein the specific feed flow rate is expressed as a ratio of a feed flow rate through the separation module and to the membrane area of the separation module;
- operating the separation module in a single pass tangential flow filtration mode at a specific feed flow rate of less than about 200 lmh into a separation module;
- and having at least one channel having a specific membrane area greater than about 40 cm−1;
- wherein the separation module comprises a plurality of serially connected spiral-wound devices for filtering the continuously supplied liquid feed stream.
3 more elements
Dependencies are inferred from the claim text.