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US 11,633,630 B2Granted
Noninvasive tissue displacement control and monitoring for neuromodulation
AssigneeGeneral Electric Company
InventorsJeffrey Michael Ashe, Christopher Michael Puleo, Victoria Eugenia Cotero, Ying Fan, Kirk Dennis Wallace, John Frederick Graf
Life of this patent
Estimating the term…
Abstract
The subject matter of the present disclosure generally relates to techniques for neuromodulation that include applying energy (e.g., ultrasound energy) into an internal tissue to cause tissue displacement and identifying that the tissue displacement has occurred. In one embodiment, the presence of tissue displacement is associated with a desired therapeutic or physiological outcome, such as a change in a molecule of interest.
Claims22
A neuromodulation delivery system, comprising:
- an energy application device configured to deliver neuromodulating energy to a region of interest of an internal tissue in a subject;
- and
- a controller configured to:
- control application of the neuromodulating energy via the energy application device to the region of interest to deliver a dose of the neuromodulating energy thereto, wherein the energy application device is controlled under control parameters;
- receive image data of the region of interest during the application of the neuromodulating energy;
- track real-time tissue displacement of the region of interest using the image data;
- calculate a rate of change of the real-time tissue displacement during delivery of a portion of the dose;
- determine that the rate of change is below a threshold indicative of a tissue displacement plateau;
- modify the control parameters to reduce the neuromodulating energy applied via the energy application device responsive to determining that the rate of change is below the threshold;
- and
- apply a remaining portion of the dose using the modified control parameters.
8 more elements
A neuromodulation delivery system, comprising:
- an ultrasound probe configured to deliver neuromodulating energy to a region of interest of an internal tissue in a subject via a therapy transducer and acquire image data of the region of interest via an imaging transducer;
- and
- a controller configured to:
- control application of the neuromodulating energy via the therapy transducer of the ultrasound probe to the region of interest to deliver a dose of the neuromodulating energy thereto, wherein the therapy transducer is controlled under control parameters;
- receive the image data of the region of interest acquired by the imaging transducer of the ultrasound probe during the application of the neuromodulating energy;
- track real-time tissue displacement of the region of interest during the application of the neuromodulating energy based on the image data;
- and
- calculate a rate of change of the real-time tissue displacement during delivery of a portion of the dose;
- compare the rate of change to a threshold indicative of a tissue displacement plateau;
- and
- modify the control parameters to reduce the neuromodulating energy applied via the therapy transducer based on the comparing;
- and
- deliver a remaining portion of the dose using the modified control parameters.
10 more elements
A method of delivery of neuromodulating energy, the method comprising:
- providing a neuromodulation delivery system comprising:
- an energy application device configured to deliver neuromodulating energy to a region of interest of an internal tissue in a subject;
- and
- a controller configured to:
- control application of the neuromodulating energy via the energy application device to the region of interest to deliver a dose of the neuromodulating energy thereto, wherein the energy application device is controlled under control parameters;
- receive image data of the region of interest during the application of the neuromodulating energy;
- track real-time tissue displacement of the region of interest using the image data;
- calculate a rate of change of the real-time tissue displacement during delivery of a portion of the dose;
- determine that the rate of change is below a threshold indicative of a tissue displacement plateau;
- modify the control parameters to reduce the neuromodulating energy applied via the energy application device responsive to determining that the rate of change is below the threshold;
- and
- apply a remaining portion of the dose using the modified control parameters
- delivering a reference pulse to the region of interest of the subject via an energy application device;
- delivering a therapy pulse to the region of interest via the energy application device subsequent to delivering the reference pulse;
- delivering a tracking pulse to the region of interest via the energy application device subsequent to delivering the therapy pulse;
- identifying a phase change between the reference pulse and the tracking pulse;
- and
- determining a tissue displacement in or near the region of interest based on the phase change.
15 more elements
A method of delivery of neuromodulating energy, the method comprising:
- providing a neuromodulation delivery system comprising:
- an energy application device configured to deliver neuromodulating energy to a region of interest of an internal tissue in a subject;
- and
- a controller configured to:
- control application of the neuromodulating energy via the energy application device to the region of interest to deliver a dose of the neuromodulating energy thereto, wherein the energy application device is controlled under control parameters;
- receive image data of the region of interest during the application of neuromodulating energy;
- track real-time tissue displacement of the region of interest using the image data;
- calculate a rate of change of the real-time tissue displacement during delivery of a portion of the dose;
- determine that the rate of change is below a threshold indicative of a tissue displacement plateau;
- modify the control parameters to reduce the neuromodulating energy applied via the energy application device responsive to determining that the rate of change is below the threshold;
- and
- apply a remaining portion of the dose using the modified control parameters
- delivering a reference pulse to the region of interest of the subject via an energy application device;
- delivering a therapy pulse to the region of interest via the energy application device subsequent to delivering the reference pulse;
- delivering a tracking pulse to the region of interest via the energy application device subsequent to delivering the therapy pulse;
- identifying a change in concentration of a molecule of interest relative to a baseline and as a result of delivering the therapy pulse;
- and
- determining a tissue displacement in or near the region of interest that is associated with the change in concentration based on a phase change between the reference pulse and the tracking pulse.
15 more elements
Dependencies are inferred from the claim text.