System and method for automated personalized brain modulation with photobiomodulation

A system for performing non-invasive photobiomodulation (PBM) therapy of a living human brain of a subject, said non-invasive PBM system comprising:

• (A) one or more configured irradiation units, each of said one or more configured irradiation units comprising:
• a portable hollow casing having fixed dimensions, a sized internal spatial volume and an external surface configuration suitable for application to a skull of the subject, said portable hollow casing being comprised of a light energy transmitting material which forms at least a portion of the configured external surface of said portable hollow casing;
• and
• at least one light generating unit housed and contained within said sized internal spatial volume of said portable hollow casing of each configured irradiation unit and which is capable of generating light energy sufficient to irradiate the skull and penetrate through the skull to pass into the brain,
• whereby said one or more configured irradiation units emit the light energy after application to the skull and achieve passage of said emitted light energy into and through the skull into at least one portion of the brain in-vivo;
• (B) a frame adapted for support of said one or more configured irradiation units and for at will placement of said light energy transmitting external surface of said one or more configured irradiation units at a fixed position and desired irradiation direction on the skull;
• (C) a configured irradiation lens comprising:
• a portable hollow casing having fixed dimensions, a sized internal spatial volume, and an external surface configuration suitable for in-vivo insertion into a nasal cavity space of a nostril without causing substantial impairment to an ability of the subject to breathe and without invading nasal tissues of the subject, said portable hollow casing being comprised of a light energy transmitting material which forms at least a portion of the configured external surface of said portable hollow casing;
• and
• at least one light generating unit housed and contained within said sized internal spatial volume of said portable hollow casing and which is capable of generating light energy sufficient to penetrate through the nasal tissues and to pass into the brain,
• whereby said configured irradiation lens emits the light energy in any desired direction within the nasal cavity after in-vivo insertion and achieve passage of said emitted light energy from the nasal cavity into at least one portion of the brain in-vivo;
• (D) a self-administrable applicator means adapted for support of said configured irradiation lens and for at will placement of said light energy transmitting external surface of said portable hollow casing of said configured irradiation lens at a fixed position and desired irradiation direction within the nostril adjacent to an internal lining of the nasal cavity of the subject;
• (E) a replenishable power source of direct electrical current;
• and
• (F) a portable controller assembly able to control delivery of the light energy from said one or more configured irradiation units and said configured irradiation lens into at least one portion of the brain in-vivo,
• said portable controller assembly comprising:
• (i) a receiving circuit for receipt of such direct electrical current as is transferred to the portable controller assembly from the power source;
• (ii) a central processing unit for controlling and directing the flow of such direct electrical current as is received by the receiving circuit;
• (iii) a delivery circuit for delivering such direct electrical current from the controller assembly to said one or more configured irradiation units and said configured irradiation lens;
• (iv) at least one connector in electrical communication with the power source for conveyance of such direct electrical current to the central processing unit;
• and
• (v) at least one connector in electrical communication with said one or more configured irradiation units for conveyance of such direct electrical current from said central processing unit to said one or more configured irradiation units and said configured irradiation lens,
• wherein the portable controller assembly controls the light energy emitted from said one or more configured irradiation units and said configured irradiation lens with respect to one or more operational parameters selected from the group consisting of wavelength, coherency, energy, power, radiant exposure, exposure time, wave type, pulse frequency, fraction protocol, duty cycle, light beam spot and light beam penetration distance;
• further comprising:
• a diagnostic tool for collecting brain activity data from the subject;
• and
• a first computing device communicatively coupled to said diagnostic tool, said first computing device being selected from the group consisting of a smart phone, a smart watch, a tablet computer, a laptop computer and a desktop computer, wherein said computing device has an analysis software application installed thereon;
• wherein the diagnostic tool transmits said collected brain activity data to the first computing device;
• wherein the analysis software application analyzes said collected brain activity data by comparing it to brain activity data of normal subjects and, based on this comparison, produces analysis data of the subject's brain activity;
• a photobiomodulation (PBM) parameter-setting software application which is installed on said first computing device or a second computing device communicatively coupled to said first computing device, said second computing device being selected from the group consisting of a smart phone, a smart watch, a tablet computer, a laptop computer and a desktop computer;
• wherein said analysis data of the subject's brain activity is transmitted to or retrieved by the PBM parameter-setting software application;
• wherein, based on said analysis data of the subject's brain activity, the PBM parameter-setting software application adjusts the one or more operational parameters of the light energy;
• and
• wherein instructions regarding the adjusted one or more operational parameters of the light energy are transmitted to the portable controller assembly, to direct the light energy with the adjusted one or more operational parameters to the subject;
• wherein the diagnostic tool, first computing device, analysis software application, second computing device and PBM parameter-setting software application are used concurrently with the system providing PBM therapy by emitting light energy to the subject, thus:
• (a) automatically producing the analysis data of the subject's brain activity in real-time;
• and (b) automatically adjusting the one or more operational parameters of the light energy in real-time and at the same time as performing PBM therapy.