Method and system for optogenetics experiments

A method for optogenetics experiments, based on wavefront shaping and comprising:

• acquiring a transmission matrix, comprising:
• using a multimode fiber as a transmission fiber for optical stimulation signals, fixing a shape of the multimode fiber, and calculating the transmission matrix between an input end and an output end of the multimode fiber under the shape;
• performing brain implant, comprising:
• implanting the output end into an intracranial space of an experimental subject, wherein the shape of the multimode fiber remains fixed before and after the brain implant;
• and
• providing an optical stimulation, comprising:
• enabling a spatial position of the optical stimulation to be within a field of view of the output end, performing wavefront compensation to a light to be input into the input end, according to the spatial position of the optical stimulation and the transmission matrix of the multimode fiber, to form a compensated expanded light, and inputting the compensated expanded light from the input end into the multimode fiber, such that the compensated expanded light, after being transmitted by the multimode fiber to the output end and output from the output end, is capable of focusing at the spatial position of the optical stimulation.