Magnetic field oscillating at several frequencies for improving efficacy and/or reducing toxicity of magnetic hyperthermia

A method of therapeutic treatment, prophylactic treatment, cosmetic treatment, or diagnosis of an individual in which magnetic particles are exposed to an oscillating magnetic field, comprising:

• administering the magnetic nanoparticles to a body part of an individual in need thereof;
• and
• applying to the body part a magnetic field oscillating either:
• (a) at a high frequency, at a medium frequency, and at a low frequency, or
• (b) at a high frequency and at a low frequency,
• wherein the high frequency applied in (a) or (b) is 1 MHz at most,
• wherein the medium frequency applied in (a) is lower than the high frequency,
• wherein the low frequency applied in (a) or (b) is lower than the high frequency, and the low frequency applied in (a) is lower than the medium frequency,
• wherein applying the oscillating magnetic field at the low frequency in (a) or (b) is part of a repetition of at least one cycle of applying the oscillating magnetic field at the low frequency, and
• wherein the at least one cycle of applying the oscillating magnetic field at the low frequency has at least one property selected from the group consisting of:
• (i) the at least one cycle of applying the oscillating magnetic field at the low frequency comprises a heating step in which the oscillating magnetic field at the low frequency induces heating and a cooling step in which the oscillating magnetic field at the low frequency induces cooling, and
• (ii) the at least one cycle of applying the oscillating magnetic field at the low frequency comprises a step with increasing oscillating magnetic field strength at the low frequency and a step with decreasing the oscillating magnetic field strength at the low frequency, and
• wherein applying the oscillating magnetic field induces at least one of a temperature increase or a movement of the magnetic nanoparticles to cause internalization or externalization of the magnetic nanoparticles from cells or death of cells in the body part to provide the therapeutic treatment, prophylactic treatment, cosmetic treatment, or diagnosis.