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US 11,633,605 B2Granted
Non-regular electrical stimulation patterns for treating neurological disorders
AssigneeDuke University
InventorsWarren M. Grill, Alan D. Dorval, II
Life of this patent
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Abstract
Systems and methods for stimulation of neurological tissue generate stimulation trains with temporal patterns of stimulation, in which the interval between electrical pulses (the inter-pulse intervals) changes or varies over time. Compared to conventional continuous, high rate pulse trains having regular (i.e., constant) inter-pulse intervals, the non-regular (i.e., not constant) pulse patterns or trains that embody features of the invention provide a lower average frequency.
Claims30
A method comprising the steps of:
- applying electrical current to targeted neurological tissue region of a brain using an implantable pulse generator comprising an electrode operatively coupled thereto, wherein the pulse generator applies electrical stimulation comprising a repeating succession of non-regular stimulation pulse trains, wherein each non-regular stimulation pulse train comprises:
- (i) a plurality of stimulation pulses having non-regular, non-random, and differing inter-pulse intervals between each of the plurality of stimulation pulses and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, and
- treating a neurological condition.
A medical stimulation system comprising;
- an implantable pulse generator operatively coupled with an electrode;
- and
- the pulse generator configured to transmit an electrical current to a neurological tissue region of a brain, the electrical current comprising a repeating succession of non-regular stimulation pulse trains, each stimulation pulse train comprising:
- (i) a plurality of stimulation pulses with non-regular, non-random, differing inter-pulse intervals between the plurality of stimulation pulses and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, whereby the pulse train treats a neurological symptom.
1 more element
A method comprising the steps of:
- applying electrical current to targeted neurological tissue region of a brain using an implantable pulse generator, wherein the pulse generator applies a non-regular pulse train comprising:
- (i) a plurality of stimulation pulses having non-regular, non-random, and differing inter-pulse intervals between each of the plurality of stimulation pulses and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, and
- repeating the applying step in succession to achieve a therapeutic purpose.
A method comprising the steps of:
- applying electrical current to targeted neurological tissue region of a brain through at least one electrode operatively coupled with an implantable pulse generator applying a non-regular pulse train comprising:
- (i) a plurality of pulses each having non-regular, non-random, differing inter-pulse intervals therebetween and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, and
- repeating the applying step in succession to modify a state of a patient to treat Parkinson Disease in the patient.
A method comprising the steps of:
- applying electrical current to targeted neurological tissue region of a brain using an implantable pulse generator, wherein the implantable pulse generator is operatively coupled with an electrode delivering a non-regular pulse train comprising:
- (i) a plurality of pulses each having non-regular, non-random, differing inter-pulse intervals therebetween and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, and
- repeating the applying step in succession to achieve a desired physiological response to treat Parkinson Disease in a patient.
A medical stimulation system comprising;
- an implantable pulse generator operatively coupled with an electrode;
- the pulse generator configured to transmit an electrical current to a neurological tissue of a brain, the electrical current comprising a non-regular pulse train, comprising:
- (i) a plurality of pulses each having non-regular, non-random, differing inter-pulse intervals therebetween and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, whereby the pulse train modifies a state of a patient to treat Parkinson Disease in the patient.
A medical stimulation system comprising;
- an implantable pulse generator operatively coupled with an electrode;
- the pulse generator configured to transmit an electrical current to a neurological tissue of a brain, the electrical current comprising a repeating succession of non-regular pulse trains, each pulse train comprising:
- (i) a plurality of pulses each having non-regular, non-random, differing inter-pulse intervals therebetween and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween, the pulse train repeating in succession to achieve a desired physiological response to treat Parkinson Disease in a patient.
A medical stimulation system comprising;
- an implantable pulse generator operatively coupled with an electrode;
- a programmable microprocessor coupled with the pulse generator;
- and
- embedded code stored on the programmable microprocessor;
- wherein the embedded code expresses programmed rules under which an electrical current is applied through the electrode to a neurological tissue of a brain, whereby the electrical current comprises a repeating succession of non-regular pulse trains, each pulse train comprising:
- (i) a plurality of pulses each having non-regular, non-random, differing inter-pulse intervals therebetween and (ii) embedded multiple pulse groups with non-regular interpulse intervals therebetween.
3 more elements
Dependencies are inferred from the claim text.