Treatment of inflammatory disorders
AssigneeGalvani Bioelectronics Limited
InventorsMargarita J. Vervoordeldonk, Robert Coatney, Cindy Cleypool
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Abstract
Modulation of the neural activity of a nerve adjacent to the left gastro epiploic artery (LGEA) and/or a nerve adjacent to a short gastric artery (SGA) can modulate the neural activity of the sympathetic nerves that impact splenic function. This is useful for reducing inflammation and providing ways of treating inflammatory disorders.
Claims17
A system for modulating neural activity in a subject's nerve adjacent to the left gastro epiploic artery (LGEA) and/or a subject's nerve adjacent to a short gastric artery (SGA) to produce a change in splenic arterial flow for treating an inflammatory disorder, and/or immune mediated inflammatory disease, the system comprising:
- at least one electrode, in signaling contact with the nerve, and
- a voltage or current source configured to generate at least one electrical signal to be applied to the nerve via the at least one electrode such that a charge density per phase applied to the nerve modulates the neural activity of the nerve to produce a change in the splenic arterial flow and further produce a change in a physiological parameter associated with the inflammatory disorder and/or immune mediated inflammatory disease in the subject,
- wherein the change in the physiological parameter is one or more of the group consisting of:
- a reduction in a pro-inflammatory cytokine, an increase in an anti-inflammatory cytokine, an increase in a catecholamine, a change in an immune cell population, a change in an immune cell surface co-stimulatory molecule, a reduction in a factor involved in the inflammation cascade, a change in the level of an immune response mediator, and a decrease in splenic blood flow.
A method for treating an inflammatory disorder and/or immune mediated inflammatory disease, comprising:
- applying an electrical signal to a subject's nerve adjacent to the left gastro epiploic artery (LGEA) and/or a subject's nerve adjacent to a short gastric artery (SGA) via at least one electrode, in signaling contact with the nerve, such that the signal reversibly modulates neural activity of the nerve to produce a change in splenic arterial flow and to produce a change in a physiological parameter associated with the inflammatory disorder and/or immune mediated inflammatory disease, in the subject,
- wherein the change in the physiological parameter is one or more of the group consisting of:
- a reduction in a pro-inflammatory cytokine, an increase in an anti-inflammatory cytokine, an increase in a catecholamine, a change in an immune cell population, a change in an immune cell surface co-stimulatory molecule, a reduction in a factor involved in the inflammation cascade, a change in the level of an immune response mediator, and a decrease in splenic blood flow.
Dependencies are inferred from the claim text.