Adaptive systems and methods for delivery of a medicament

A method of delivering a plurality of sequential doses of an active substance to a user over a stage of trials, wherein the stage of trials comprises a plurality of sequential administration trials, the method comprising:

• a. determining the values of the plurality of sequential doses to be delivered, so that the sum of the differences between each administrated dose and the dose administered in the immediately preceding trial, divided by the number of the plurality of the sequential administration trials of said stage of trials, is greater than zero, and so that the number of differences between the dose administered in a trial and the dose administered in the immediately preceding trial that are less than zero is greater than the number of differences between the dose administered in a trial and the dose administered in the immediately preceding trial that are greater than zero;
• and
• b. delivering the plurality of sequential doses of the active substance over the sequential administration trials,
• whereby the physiological effects associated with the active substance will be increased.

A method of delivering a plurality of sequential doses of a vaporizable material to a user of a vaporizing device over a stage of puffs, wherein the stage of puffs comprises a plurality of sequential administration puffs, and wherein the vaporizing device includes a heater controller, a heater, a source of the vaporizable material, a dose computation unit, a dose delivery unit, a puff duration predictor unit, the method comprising:

• a. calculating the values of the plurality of sequential doses in the dose computation unit, so that the sum of the differences between each administrated dose and the dose administered in the immediately preceding puff, divided by the number of the plurality of the sequential administration puffs of said stage of puffs, is greater than zero, and so that the number of differences between the dose administered in a puff and the dose administered in the immediately preceding puff that are less than zero is greater than the number of differences between the dose administered in a puff and the dose administered in the immediately preceding puff that are greater than zero;
• b. transmitting the value of the plurality of sequential doses from the dose computation unit to the dose delivery unit;
• c. predicting the puff topography features of a incoming puff in the puff duration predictor unit;
• d. transmitting the puff topography features from the puff duration predictor unit to the dose delivery unit;
• e. calculating, for the time duration of the incoming puff a power profile in the dose delivery unit;
• f. delivering the power profile from the heater controller to the heater for vaporizing the vaporizable material in the source of the vaporizable material over the time duration of the incoming puff;
• g. computing a total delivered dose of vapor in the dose delivery unit;
• h. transmitting the value of the total delivered dose of vapor from the dose delivery unit to the dose computation unit,
• i. whereby the physiological effects associated with the vaporizable material will be increased.