Pharmaceutical container and liquid composition
AssigneeSCHOTT Pharma AG & Co. KGaA
InventorsElmar Horsch, Tanja Woywod
Life of this patent
Estimating the term…
Abstract
A pharmaceutical container for drug delivery includes a barrel configured to slidably receive a stopper. The stopper has a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition. The stopper has a circumferential surface partially contacting an inner surface of the barrel. A surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness.
Claims19
A pharmaceutical container for drug delivery, comprising:
- a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, a surface roughness of the inner surface of the barrel declines from the stopper's start position to its end position by at least 3% of at least one of Ra roughness or Rms roughness, wherein the inner surface of the barrel has a water contact angle of at least 80°, wherein the inner surface of the barrel is uncoated.
A pharmaceutical container, comprising:
- a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, the stopper having a start position SP, a middle position MP, and an end position EP within the barrel, the inner surface of the barrel having a surface roughness and a surface roughness distribution such that the surface roughness measured at the start position SP, the middle position MP, and the end position EP is as follows:
- SP 100% of the surface roughness;
- MP 40% to 60% of the surface roughness;
- and
- EP 20% to 35% of the surface roughness.
A pharmaceutical container, comprising:
- a barrel configured to slidably receive a stopper, the stopper having a proximal end suitable for contacting a plunger rod and a distal end suitable for contacting a pharmaceutical composition, the stopper having a circumferential surface partially contacting an inner surface of the barrel, the stopper having a start position SP, a middle position MP, and an end position EP within the barrel, the barrel being at least partially tapered such that compression of the stopper by the barrel increases as the stopper moves from the start position to the end position, the pharmaceutical container exhibiting a total glide force variation TGFV=GFmax−GFmin measured when the stopper is moved from the start position to the end position that is TGFV<2 N.
Dependencies are inferred from the claim text.