Blood filtration systems

A blood filtration system for reducing one or more plasma constituents in blood of a patient, the system comprising:

• a variable-speed blood pump configured to pump blood in a withdrawal line, through a filter, and into an infusion line, wherein:
• the withdrawal line and the infusion line are configured to couple with a catheter, and the catheter is configured for insertion into a blood stream of the patient and
• the withdrawal line and the infusion line are configured to couple with the filter, and the filter is configured to reduce an amount of one or more plasma constituents in blood flowing through the filter and provide a filtrate fluid including the plasma constituents;
• a first pressure sensor in communication with the withdrawal line;
• a second pressure sensor in communication with the infusion line;
• a variable speed filtration pump configured to extract the filtrate fluid from the filter at an extraction rate, and the extraction rate is variable according to a speed of the filtration pump;
• and
• a controller including processing circuitry, wherein the controller is configured to:
• adjust a speed of the blood pump to vary a flow rate of the blood through the filter;
• adjust a speed of the filtration pump to vary the extraction rate of the filtrate fluid from the filter;
• determine a venous pressure of the patient, wherein determining the venous pressure of the patient includes determining a pressure differential between the first pressure sensor and the second pressure sensor;
• and
• provide a notification of the venous pressure of the patient.