Apparatus for removing chemotherapy compounds from blood
AssigneeDelcath Systems, Inc.
InventorsDaniel S. Johnston, Jacques Chammas, William M. Appling, Samantha J. Barton
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Abstract
A filter apparatus for removing small molecule chemotherapy agents from blood is provided. The filter apparatus comprises a housing with an extraction media comprised of polymer coated carbon cores. Also provided are methods of treating a subject with cancer of an organ or region comprising administering a chemotherapeutic agent to the organ or region, collecting blood laded with chemotherapeutic agent from the isolated organ, filtering the blood laden with chemotherapeutic agent to reduce the chemotherapeutic agent in the blood and returning the blood to the subject.
Claims29
A percutaneous hepatic perfusion procedure for treating a patient with a liver cancer, comprising:
- isolating blood flow from the liver with catheters to obtain an isolated liver;
- delivering a chemotherapy agent to the isolated liver;
- perfusing the chemotherapy agent in the isolated liver for a period of time sufficient to provide a therapeutic effect;
- filtering blood drained from the isolated liver after perfusing with a filter comprising hemocompatible polymer coated carbon cores, wherein the carbon cores have a pore volume of about 1.68 cc/g to about 2.19 cc/g, to provide filtered blood, and
- returning the filtered blood to the patient.
A percutaneous hepatic perfusion procedure for treating a patient with a liver cancer, comprising:
- isolating blood flow from the liver with catheters to provide an isolated liver;
- delivering a chemotherapy agent to the isolated liver;
- perfusing the chemotherapy agent in the isolated liver for a period of time sufficient to provide a therapeutic effect;
- filtering blood drained from the isolated liver after perfusing with a filter comprising hemocompatible polymer coated carbon cores, wherein the carbon cores have an apparent density of about 0.19 g/cc to about 0.2 g/cc, to provide filtered blood, and
- returning the filtered blood to the patient.
A percutaneous hepatic perfusion procedure for treating a patient with a liver cancer, comprising:
- isolating blood flow from the liver with catheters to provide an isolated liver;
- delivering a chemotherapy agent to the isolated liver;
- perfusing the chemotherapy agent in the isolated liver for a period of time sufficient to provide a therapeutic effect;
- filtering blood drained from the isolated liver after perfusing with a filter comprising hemocompatible polymer coated carbon cores, wherein the carbon cores have an apparent density less than about 0.2 g/cc, to provide filtered blood, and
- returning the filtered blood to the patient.
A percutaneous hepatic perfusion method for treating a patient with a liver cancer, comprising:
- isolating blood flow from the liver with catheters to provide an isolated liver;
- administering a chemotherapy agent arterially to the isolated liver;
- perfusing the chemotherapy agent in the isolated liver for a period of time sufficient to provide a therapeutic effect;
- filtering blood drained from the isolated liver after perfusing with a filter comprising hemocompatible polymer coated carbon cores, wherein the carbon cores have an apparent density of is less than about 0.2 g/cc, to provide filtered blood, and
- returning the filtered blood to the patient.
A filter media comprising:
- hemocompatible polymer coated carbon cores, the carbon cores having a pore volume of about 1.68 cc/g to about 2.19 cc/g, a particle diameter of about 0.45 mm to about 1.15 mm, and an apparent density of about 0.19 g/cc to about 0.2 g/cc, and
- wherein the hemocompatible polymer is a semipermeable polymer selected from a group consisting of cellulose, a methacrylate polymer and combinations thereof.
Dependencies are inferred from the claim text.