Perforated tissue graft
AssigneeTEI Biosciences, Inc.
InventorsKevin Cornwell, Kenneth James
Life of this patent
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Abstract
A tissue graft for soft tissue repair or reconstruction comprising a sheet of a biopolymer-based matrix having a plurality of small perforations and a plurality of large perforations. The small perforations are sized to facilitate clotting and granulation tissue development within the perforations which, in turn, facilitates revascularization and cell repopulation in the patient. The large perforations are sized to reduce the occurrence of clotting and granulation tissue development within the perforations so that extravascular tissue fluids accumulating at the implant site can drain through the tissue graft. The large perforations enhance mammal tissue anchoring by permitting mammal tissue to compress into the perforations increasing mammal tissue contact area.
Claims23
A tissue graft comprising:
- a sheet of a tissue graft material having a plurality of rows of small perforations, which pass through the sheet, and a plurality of rows of large perforations, which pass through the sheet;
- wherein the small perforations are smaller in size than the large perforations;
- wherein the small perforations have a diameter that is less than 3 mm and the large perforations have a diameter that is greater than 3 mm;
- wherein the diameters of the small perforations and the large perforations are in a ratio of about 1:1.2 to about 1:2.0;
- wherein the tissue graft has a thickness in a range of about 2 mm;
- wherein the tissue graft material is acellular animal dermis;
- wherein the rows of small perforations are substantially parallel to the rows of large perforations;
- and
- wherein the rows of small perforations alternate with the rows of large perforations, such that one small perforation is centered about every four adjacent large perforations, which are arranged in a substantially square or rectangular manner about the one small perforation, and one large perforation is centered about every four adjacent small perforations, which are arranged in a substantially square or rectangular manner about the one large perforation.
A method of repairing or constructing tissue in a patient, comprising:
- providing a tissue graft comprising:
- a sheet of a tissue graft material and having a plurality of small perforations, which pass through the sheet, and a plurality of large perforations, which pass through the sheet;
- wherein the small perforations are smaller in size than the large perforations;
- wherein the small perforations have a diameter that is less than 3 mm and the large perforations have a diameter that is greater than 3 mm;
- wherein the diameters of the small perforations and the large perforations are in a ratio of about 1:1.2 to about 1:2.0;
- wherein the tissue graft has a thickness in a range of about 2 mm;
- wherein the tissue graft material is acellular animal dermis;
- wherein the rows of small perforations are substantially parallel to the rows of large perforations;
- wherein the rows of small perforations alternate with the rows of large perforations, such that one small perforation is centered about every four adjacent large perforations, which are arranged in a substantially square or rectangular manner about the one small perforation, and one large perforation is centered about every four adjacent small perforations, which are arranged in a substantially square or rectangular manner about the one large perforation;
- applying the tissue graft to the patient at an implant site;
- and
- allowing revascularization and cell repopulation in the patient.
Dependencies are inferred from the claim text.