Dried implant composition and injectable aqueous implant formulation
AssigneeGeistlich Pharma AG
InventorsDaniel Suppiger, Paul Buxton, Nino Kurz
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Abstract
A dried implant composition for preparing an injectable aqueous implant formulation that is extrudable through a tapering system and a gauge 18 cannula, including a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve; an injectable aqueous implant formulation, wherein the injectable aqueous implant formulation is obtainable by hydration and homogeneous mixing; a process for preparing the injectable aqueous implant formulation; and a kit for preparing the injectable aqueous implant formulation.
Claims18
A syringe containing a dried mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of the nanocrystalline hydroxyapatite particles to the naturally crosslinked fibrous collagen material is from 1.8 to 4.5.
An injectable aqueous implant formulation, wherein the injectable aqueous implant formulation comprises 25-45 w/w % of a dried implant composition consisting essentially of a mixture of nanocrystalline hydroxyapatite particles derived from natural bone having a size of 50 to 200 μm and fragments of naturally crosslinked fibrous collagen material that pass through a 0.5 mm sieve, whereby the w/w ratio of the nanocrystalline hydroxyapatite particles to collagen is from 1.8 to 4.5, homogenized in a pharmaceutically acceptable aqueous vehicle, wherein the injectable aqueous implant formulation having properties such that it is extrudable through a tapering system and an 18 gauge (0.838 mm inner diameter) 25.4 mm long cannula with a force not exceeding 60 N.
Dependencies are inferred from the claim text.