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US 11,633,507 B2Granted
HER2 binders
AssigneesGeneral Electric Company, Affibody AB
InventorsFaisal Ahmed Syud, Brian Duh-Lan Lee, Rong Zhang, Peter Brian Iveson, Paul Schaffer, Tove Simonsson, Elin Gunneriusson, Fredrik Frejd, Lars Abrahmsen, Joachim Feldwisch, Nina Herne, Christofer Lendel
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Abstract
Imaging agents comprising an isolated polypeptide conjugated with a radionucleide and a chelator; wherein the isolated polypeptide binds specifically to HER2, or a variant thereof; and methods for preparing and using these imaging agents.
Claims8
An imaging compound comprising:
- an isolated polypeptide and an 18F radioisotope coupled to the polypeptide through a bifunctional linker molecule, wherein the radioisotope is coupled to the bifunctional linker via an aminoxy group, an azido group, or an alkyne group,
- wherein the isolated polypeptide comprises SEQ ID No:
- 1 or SEQ ID No:
- 2, and
- wherein the isolated polypeptide binds specifically to HER2.
2 more elements
An imaging compound comprising:
- an isolated polypeptide comprising SEQ ID No:
- 2 conjugated with a 18F radioisotope via a tert-butyl 2-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylamino)-2-oxoethoxycarbamate linker, wherein the isolated polypeptide binds specifically to HER2.
Dependencies are inferred from the claim text.