Back to results
US 11,633,504 B2Granted
Nucleic acids encoding clotting factor variants and their use
AssigneesEmory University, Children's Healthcare of Atlanta, Inc., Georgia Tech Research Corporation
InventorsChristopher Doering, Harold Trent Spencer, Eric Gaucher, Caelan Radford
Life of this patent
Estimating the term…
Abstract
Disclosed herein are novel variants of clotting factors VII, VIII, and IX and their use, for example, in methods of treating a subject with a clotting disorder, such as hemophilia A or hemophilia B.
Claims11
An isolated nucleic acid molecule, comprising:
- a nucleic acid sequence encoding a Factor IX (fIX) protein comprising an amino acid sequence at least 95% identical to residues 47-462 of SEQ ID NO:
- 23 (An96 fIX);
- wherein the fIX protein has increased blood clotting activity relative to human fIX.
Dependencies are inferred from the claim text.