Anti-TMEM-180 antibody, anticancer drug and cancer testing method

A method of diagnosing colon cancer in a human subject, comprising a step of detecting the existence or amount of exosomes having TMEM-180 or the existence or amount of TMEM-180 expression on exosomes in a body fluid sample obtained from the human subject by using an antibody binding to transmembrane protein 180 (TMEM-180) or an antigen-binding fragment thereof,

• wherein the body fluid is a blood sample, wherein the existence of exosomes having TMEM-180 and the existence of TMEM-180 expression on exosomes indicate that the human subject has a colon cancer secreting exosomes presenting TMEM-180 to the body fluid, and
• wherein the antibody and the fragment thereof each comprise:
• a heavy chain variable region having
• a heavy chain CDR1 having DYWVS (SEQ ID NO:
• 72);
• a heavy chain CDR2 having EIYPNSGATNFNENFK (SEQ ID NO:
• 73);
• and
• a heavy chain CDR3 having DGTMGIAYYFDY (SEQ ID NO:
• 74);
• and
• a light chain variable region having
• a light chain CDR1 having KASQNINRYLN (SEQ ID NO:
• 75);
• a light chain CDR2 having NANSLQT (SEQ ID NO:
• 76);
• and
• a light chain CDR3 having LQHNSWPYT (SEQ ID NO:
• 77).