Compositions

A thermostable liquid immunogenic composition comprising:

• a human live attenuated rotavirus,
• sucrose,
• adipic acid,
• calcium ions,
• histidine, and
• vitamin E succinate (VES);
• wherein said immunogenic composition is in the form of liquid formulations;
• wherein said composition has a level of thermostability such that, after storage of the composition for 2.5 months at 37° C., the composition has a maximum virus titer loss of 1.5, as expressed in log10 ffu/mL as compared to the composition's initial virus titer before storage;
• wherein
• rotavirus is present at an initial titer ranging from 1×105 to 1×108 pfu/mL;
• the concentration of sucrose is 10% w/v;
• the adipic acid is present at a concentration of 6.7% w/v;
• the calcium ions are present at a concentration from 5 mM;
• the VES is present at a concentration of no more than 1.5 mM;
• the histidine is present at a concentration of 0.2%;
• the arginine is present at a concentration of 0.2% w/v.