Immunogenic composition and vaccine for generating an immune response to norovirus
AssigneeIcon Genetics GmbH
InventorsVesna Blazevic, Maria Malm, Frank Thieme, Franziska Jarczowski, Andre Diessner, Victor Klimyuk
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Abstract
An immunogenic composition comprising at least one Norovirus antigen and at least one adjuvant which is at least one B subunit of an AB5 toxin such as cholera toxin subunit B (CTB) or the B subunit of heat-labile E. coli exotoxin LT (LTB).
Claims17
A combination vaccine for preventing and/or treating Norovirus infection and infection by a bacterial pathogen in a mammal, said vaccine comprising at least one noroviral antigen and a B subunit of a bacterial ABs toxin capable of generating an immune response against said bacterial pathogen, and a pharmaceutically acceptable carrier, wherein said bacterial pathogen is E. coli and wherein said B subunit of bacterial AB5 toxin is a B subunit of E. coli heat-labile enterotoxin (LTB).
A method of preventing and/or treating norovirus infection and/or for reducing the severity of norovirus infection, comprising administering an immunogenic composition comprising at least one norovirus antigen and at least one B subunit of an AB5 toxin to a subject by parenteral administration of the immunogenic composition selected from intradermal, intramuscular and subcutaneous administration, wherein said B subunit is a B subunit of E. coli heat-labile enterotoxin (LTB).
A method of preventing and/or treating Norovirus infection and infection by a bacterial pathogen in a mammal, comprising administering to a subject an immunogenic composition comprising at least one noroviral antigen and a B subunit of a bacterial ABs toxin capable of generating an immune response against said bacterial pathogen, wherein said bacterial pathogen is E Coli and wherein said B subunit of bacterial AB5 toxin is a B subunit of E. coli heat-labile enterotoxin (LTB).
A method of preventing and/or treating Norovirus infection and infection by a bacterial pathogen in a mammal, comprising administering to a subject an immunogenic composition comprising at least one norovirus antigen and a B subunit of a bacterial AB5 toxin capable of generating an immune response against said bacterial pathogen, wherein said bacterial pathogen is E. coli and wherein said B subunit of bacterial AB5 toxin is a B subunit of E. coli heat-labile enterotoxin (LTB).
Dependencies are inferred from the claim text.