Enteric fever vaccine based on outer membrane vesicles from two different strains of typhoidal Salmonelle species
AssigneeIndian Council of Medical Research
InventorsHemanta Koley, Debaki Ranjan Howlader, Shanta Dutta
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Abstract
A novel consortium used as potent vaccine for treating of enteric fever, comprised of isolated Outer Membrane Vesicles (OMVs) taken from two different strains of typhoidal Salmonella species.
Claims7
A bivalent formulation for enteric fever, the bivalent formulation comprising outer membrane vesicles (OMVs) isolated from unmutated Salmonella typhi C-6953 and Salmonella paratyphi A C-6915, wherein Salmonella typhi C-6953 and Salmonella paratyphi A C-6915 OMVs are present in a ratio of 1:1, wherein the bivalent formulation is free of antibiotics, excipients, and protective proteins, and wherein the Salmonella typhi C-6953 and Salmonella paratyphi A C-6915 are cultured in absence of a minimal medium prior to the isolation of the OMVs.
Dependencies are inferred from the claim text.