Pharmaceutical composition comprising plasminogen and uses thereof
AssigneePrometic Biotherapeutics, Inc.
InventorsDavida Blackman, Stacy Plum, William Garzon-Rodriguez, Martin Robitaille, Betty Yu
Life of this patent
Estimating the term…
Abstract
Pharmaceutical compositions comprising plasminogen or a biologically active variant thereof are disclosed. In an embodiment, the composition comprises a tonicity modifier, a bulking agent, and a stabilising agent and has a pH of about 3.0 to about 10.0. In another embodiment, the composition contains an amount of particles in suspension equal to or greater than 10 μm which is lower than 6000 particles per 100 ml, and preferably lower than 2000 particles per 100 ml. Uses of these compositions as a medicament is contemplated. Various therapeutic uses of these pharmaceutical compositions is also contemplated.
Claims20
A method for treating plasminogen-deficiency and/or improving wound healing in a subject in need thereof, said method comprises administering to the subject an effective amount of a liquid pharmaceutical composition having an osmolality of 180 mOsm to 350 mOsm and a pH of 5 to 8 and comprising:
- native human Glu-plasminogen, or a biologically active variant thereof having at least 90% amino acid sequence identity with native human Glu-plasminogen, in a concentration from 2 mg/ml to 60 mg/ml;
- and
- a stabilising agent, which is arginine, an arginine salt, glycine or a glycine salt, in a concentration from 10 to 200 mM.
Dependencies are inferred from the claim text.