Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use
AssigneeBoise State University
InventorsCheryl Jorcyk, Don Warner, Matthew David King, Lisa Warner
Life of this patent
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Abstract
A method of treating cancer or metastasis is provided involving administering at least one oncostatin M (OSM) antagonist to a subject, wherein the subject has been diagnosed with cancer. Administration of an OSM antagonist such as a small molecule pharmaceutical is provided as well as an anti-OSM antibody, an anti-OSM aptamer, and an OSM mRNA antagonist. The OSM antagonists were found to inhibit or prevent tumor cell detachment, progression, proliferation and metastasis in several cancer types.
Claims31
A method of inhibiting or reducing tumor cell detachment, progression, proliferation and/or metastasis comprising:
- administering to a subject an effective amount of one or more OSM small molecule antagonists from the group of:
- OSM-SMI-8A, OSM-SMI-8B, OSM-SMI-8C, OSM-SMI-8D, OSM-SMI-8E, OSM-SMI-8F, OSM-SMI-8G, OSM-SMI-8H, OSM-SMI-8I, OSM-SMI-8J, OSM-SMI-8N1, OSM-SMI-10A, OSM-SMI-10B, OSM-SMI-10B-2, OSM-SMI-10B-3, OSM-SMI-10B-4, OSM-SMI-10B-5, OSM-SMI-10B-6, OSM-SMI-10B-7, OSM-SMI-10B-8, OSM-SMI-10B-9, OSM-SMI-10B-10, OSM-SMI-10B-11, OSM-SMI-10B-12, OSM-SMI-10B-13, OSM-SMI-10B-14, OSM-SMI-10B-15, OSM-SMI-10B-16, OSM-SMI-10B-17, OSM-SMI-10B-18, OSM-SMI-10B-19, OSM-SMI-10B-20, OSM-SMI-10B-21, OSM-SMI-10B-22, OSM-SMI-10B-23, OSM-SMI-10B-24, OSM-SMI-10B-25, OSM-SMI-10B-26, OSM-SMI-10B-27, OSM-SMI-10B-28, OSM-SMI-10B-29, OSM-SMI-10B-30, OSM-SMI-10B-31, OSM-SMI-10B-32, OSM-SMI-10B-33, OSM-SMI-10B-34, OSM-SMI-10B-35, OSM-SMI-10B-36, OSM-SMI-10B-37, OSM-SMI-10C, OSM-SMI-10D, OSM-SMI-10E, OSM-SMI-10F, OSM-SMI-10G, OSM-SMI-10H, OSM-SMI-10I, OSM-SMI-10J, OSM-SMI-10K, OSM-SMI-10L, OSM-SMI-10M, OSM-SMI-10N, OSM-SMI-10O, OSM-SMI-10P, OSM-SMI-10Q, OSM-SMI-10R, OSM-SMI-10S, OSM-SMI-23, OSM-SMI-23A, OSM-SMI-23B, OSM-SMI-23C, OSM-SMI-23D, OSM-SMI-23E, OSM-SMI-23F, OSM-SMI-23G, OSM-SMI-23H, OSM-SMI-23I, OSM-SMI-23J, OSM-SMI-23K, OSM-SMI-23L, OSM-SMI-23M, OSM-SMI-23N, OSM-SMI-23O, OSM-SMI-23P, OSM-SMI-23R, OSM-SMI-26, OSM-SMI-26A, OSM-SMI-26B, OSM-SMI-26C, OSM-SMI-26D, OSM-SMI-26E, OSM-SMI-26F, OSM-SMI-26G, OSM-SMI-26H, OSM-SMI-26I, OSM-SMI-26J, OSM-SMI-26K, OSM-SMI-26L, OSM-SMI-26M, OSM-SMI-26N, OSM-SMI-26O, OSM-SMI-26P, OSM-SMI-26Q, OSM-SMI-27, OSM-SMI-27-A1, OSM-SMI-27-A2, OSM-SMI-27-A3, OSM-SMI-27-A4, OSM-SMI-27-A5, OSM-SMI-27-A6, OSM-SMI-27-A7, OSM-SMI-27-A8, OSM-SMI-27-A9, OSM-SMI-27-A10, OSM-SMI-27-A11, OSM-SMI-27-B0, OSM-SMI-27-B1, OSM-SMI-27-B2, OSM-SMI-27-B3, OSM-SMI-27-B4, OSM-SMI-27-B5, OSM-SMI-27-B6, OSM-SMI-27-B7, OSM-SMI-27-B8, OSM-SMI-27-B9, OSM-SMI-27-B10, OSM-SMI-27-B11, OSM-SMI-27-C0, OSM-SMI-27-C1, OSM-SMI-27-C2, OSM-SMI-27-C3, OSM-SMI-27-C4, OSM-SMI-27-C5, OSM-SMI-27-C6, OSM-SMI-27-C7, OSM-SMI-27-C8, OSM-SMI-27-C9, OSM-SMI-27-C10, OSM-SMI-27-C11, OSM-SMI-27-Z1, OSM-SMI-27-Y1, OSM-SMI-27-Y2, OSM-SMI-27-X1, OSM-SMI-27-X2, OSM-SMI-27-X3, OSM-SMI-27-X4, OSM-SMI-27-W1, OSM-SMI-27-W2, OSM-SMI-27-W3, OSM-SMI-27-W4, OSM-SMI-27-W5, OSM-SMI-27-W6, OSM-SMI-27-V1, OSM-SMI-27-V2, OSM-SMI-27-V3, OSM-SMI-27-V4, OSM-SMI-27-V5, OSM-SMI-27-V6, OSM-SMI-27-U1, OSM-SMI-27-U2, OSM-SMI-27-U3, OSM-SMI-27-U4, OSM-SMI-27-T1, OSM-SMI-27-T2, and/or OSM-SMI-27-T3.
A pharmaceutical composition comprising a unit dose of at least 1 mg of a small molecule antagonist to oncostatin M (OSM), wherein the small molecule antagonist of oncostatin M is selected from the group consisting of OSM-SMI-8A, OSM-SMI-8B, OSM-SMI-8C, OSM-SMI-8D, OSM-SMI-8E, OSM-SMI-8F, OSM-SMI-8G, OSM-SMI-8H, OSM-SMI-8I, OSM-SMI-8J, OSM-SMI-8N1, OSM-SMI-10A, OSM-SMI-10B, OSM-SMI-10B-2, OSM-SMI-10B-3, OSM-SMI-10B-4, OSM-SMI-10B-5, OSM-SMI-10B-6, OSM-SMI-10B-7, OSM-SMI-10B-8, OSM-SMI-10B-9, OSM-SMI-10B-10, OSM-SMI-10B-11, OSM-SMI-10B-12, OSM-SMI-10B-13, OSM-SMI-10B-14, OSM-SMI-10B-15, OSM-SMI-10B-16, OSM-SMI-10B-17, OSM-SMI-10B-18, OSM-SMI-10B-19, OSM-SMI-10B-20, OSM-SMI-10B-21, OSM-SMI-10B-22, OSM-SMI-10B-23, OSM-SMI-10B-24, OSM-SMI-10B-25, OSM-SMI-10B-26, OSM-SMI-10B-27, OSM-SMI-10B-28, OSM-SMI-10B-29, OSM-SMI-10B-30, OSM-SMI-10B-31, OSM-SMI-10B-32, OSM-SMI-10B-33, OSM-SMI-10B-34, OSM-SMI-10B-35, OSM-SMI-10B-36, OSM-SMI-10B-37, OSM-SMI-10C, OSM-SMI-10D, OSM-SMI-10E, OSM-SMI-10F, OSM-SMI-10G, OSM-SMI-10H, OSM-SMI-10I, OSM-SMI-10J, OSM-SMI-10K, OSM-SMI-10L, OSM-SMI-10M, OSM-SMI-10N, OSM-SMI-100, OSM-SMI-10P, OSM-SMI-10Q, OSM-SMI-10R, OSM-SMI-108, OSM-SMI-23, OSM-SMI-23A, OSM-SMI-23B, OSM-SMI-23C, OSM-SMI-23D, OSM-SMI-23E, OSM-SMI-23F, OSM-SMI-23G, OSM-SMI-23H, OSM-SMI-231, OSM-SMI-23J, OSM-SMI-23K, OSM-SMI-23L, OSM-SMI-23M, OSM-SMI-23N, OSM-SMI-230, OSM-SMI-23P, OSM-SMI-23Q, OSM-SMI-23R, OSM-SMI-26, OSM-SMI-26A, OSM-SMI-26B, OSM-SMI-26C, OSM-SMI-26D, OSM-SMI-26E, OSM-SMI-26F, OSM-SMI-26G, OSM-SMI-26H, OSM-SMI-26I, OSM-SMI-26J, OSM-SMI-26K, OSM-SMI-26L, OSM-SMI-26M, OSM-SMI-26N, OSM-SMI-260, OSM-SMI-26P, OSM-SMI-26Q, OSM-SMI-27, OSM-SMI-27-A1, OSM-SMI-27-A2, OSM-SMI-27-A3, OSM-SMI-27-A4, OSM-SMI-27-A5, OSM-SMI-27-A6, OSM-SMI-27-A7, OSM-SMI-27-A8, OSM-SMI-27-A9, OSM-SMI-27-A10, OSM-SMI-27-A11, OSM-SMI-27-B0, OSM-SMI-27-B1, OSM-SMI-27-B2, OSM-SMI-27-B3, OSM-SMI-27-B4, OSM-SMI-27-B5, OSM-SMI-27-B6, OSM-SMI-27-B7, OSM-SMI-27-B8, OSM-SMI-27-B9, OSM-SMI-27-B10, OSM-SMI-27-B11, OSM-SMI-27-CO, OSM-SMI-27-C1, OSM-SMI-27-C2, OSM-SMI-27-C3, OSM-SMI-27-C4, OSM-SMI-27-C5, OSM-SMI-27-C6, OSM-SMI-27-C7, OSM-SMI-27-C8, OSM-SMI-27-C9, OSM-SMI-27-C10, OSM-SMI-27-C11, OSM-SMI-27-Z1, OSM-SMI-27-Y 1, OSM-SMI-27-Y2, OSM-SMI-27-X1, OSM-SMI-27-X2, OSM-SMI-27-X3, OSM-SMI-27-X4, OSM-SMI-27-W1, OSM-SMI-27-W2, OSM-SMI-27-W3, OSM-SMI-27-W4, OSM-SMI-27-W5, OSM-SMI-27-W6, OSM-SMI-27-V1, OSM-SMI-27-V2, OSM-SMI-27-V3, OSM-SMI-27-V4, OSM-SMI-27-V5, OSM-SMI-27-V6, OSM-SMI-27-U1, OSM-SMI-27-U2, OSM-SMI-27-U3, OSM-SMI-27-U4, OSM-SMI-27-T1, OSM-SMI-27-T2 and a pharmaceutically acceptable carrier.
A pharmaceutical composition for use in inhibiting or reducing tumor cell detachment, proliferation and/or metastasis, comprising an effective amount of an antagonist to OSM, wherein the OSM antagonist is one or more of OSM-SMI-8A, OSM-SMI-8B, OSM-SMI-8C, OSM-SMI-8D, OSM-SMI-8E, OSM-SMI-8F, OSM-SMI-8G, OSM-SMI-8H, OSM-SMI-8I, OSM-SMI-8J, OSM-SMI-8N1, OSM-SMI-10A, OSM-SMI-10B, OSM-SMI-10B-2, OSM-SMI-10B-3, OSM-SMI-10B-4, OSM-SMI-10B-5, OSM-SMI-10B-6, OSM-SMI-10B-7, OSM-SMI-10B-8, OSM-SMI-10B-9, OSM-SMI-10B-10, OSM-SMI-10B-11, OSM-SMI-10B-12, OSM-SMI-10B-13, OSM-SMI-10B-14, OSM-SMI-10B-15, OSM-SMI-10B-16, OSM-SMI-10B-17, OSM-SMI-10B-18, OSM-SMI-10B-19, OSM-SMI-10B-20, OSM-SMI-10B-21, OSM-SMI-10B-22, OSM-SMI-10B-23, OSM-SMI-10B-24, OSM-SMI-10B-25, OSM-SMI-10B-26, OSM-SMI-10B-27, OSM-SMI-10B-28, OSM-SMI-10B-29, OSM-SMI-10B-30, OSM-SMI-10B-31, OSM-SMI-10B-32, OSM-SMI-10B-33, OSM-SMI-10B-34, OSM-SMI-10B-35, OSM-SMI-10B-36, OSM-SMI-10B-37, OSM-SMI-10C, OSM-SMI-10D, OSM-SMI-10E, OSM-SMI-10F, OSM-SMI-10G, OSM-SMI-10H, OSM-SMI-10I, OSM-SMI-10J, OSM-SMI-10K, OSM-SMI-10L, OSM-SMI-10M, OSM-SMI-10N, OSM-SMI-10O, OSM-SMI-10P, OSM-SMI-10Q, OSM-SMI-10R, OSM-SMI-10S, OSM-SMI-23, OSM-SMI-23A, OSM-SMI-23B, OSM-SMI-23C, OSM-SMI-23D, OSM-SMI-23E, OSM-SMI-23F, OSM-SMI-23G, OSM-SMI-23H, OSM-SMI-23I, OSM-SMI-23J, OSM-SMI-23K, OSM-SMI-23L, OSM-SMI-23M, OSM-SMI-23N, OSM-SMI-23O, OSM-SMI-23P, OSM-SMI-23R, OSM-SMI-26, OSM-SMI-26A, OSM-SMI-26B, OSM-SMI-26C, OSM-SMI-26D, OSM-SMI-26E, OSM-SMI-26F, OSM-SMI-26G, OSM-SMI-26H, OSM-SMI-26I, OSM-SMI-26J, OSM-SMI-26K, OSM-SMI-26L, OSM-SMI-26M, OSM-SMI-26N, OSM-SMI-26O, OSM-SMI-26P, OSM-SMI-26Q, OSM-SMI-27, OSM-SMI-27-A1, OSM-SMI-27-A2, OSM-SMI-27-A3, OSM-SMI-27-A4, OSM-SMI-27-A5, OSM-SMI-27-A6, OSM-SMI-27-A7, OSM-SMI-27-A8, OSM-SMI-27-A9, OSM-SMI-27-A10, OSM-SMI-27-A11, OSM-SMI-27-B0, OSM-SMI-27-B1, OSM-SMI-27-B2, OSM-SMI-27-B3, OSM-SMI-27-B4, OSM-SMI-27-B5, OSM-SMI-27-B6, OSM-SMI-27-B7, OSM-SMI-27-B8, OSM-SMI-27-B9, OSM-SMI-27-B10, OSM-SMI-27-B11, OSM-SMI-27-C0, OSM-SMI-27-C1, OSM-SMI-27-C2, OSM-SMI-27-C3, OSM-SMI-27-C4, OSM-SMI-27-C5, OSM-SMI-27-C6, OSM-SMI-27-C7, OSM-SMI-27-C8, OSM-SMI-27-C9, OSM-SMI-27-C10, OSM-SMI-27-C11, OSM-SMI-27-Z1, OSM-SMI-27-Y1, OSM-SMI-27-Y2, OSM-SMI-27-X1, OSM-SMI-27-X2, OSM-SMI-27-X3, OSM-SMI-27-X4, OSM-SMI-27-W1, OSM-SMI-27-W2, OSM-SMI-27-W3, OSM-SMI-27-W4, OSM-SMI-27-W5, OSM-SMI-27-W6, OSM-SMI-27-V1, OSM-SMI-27-V2, OSM-SMI-27-V3, OSM-SMI-27-V4, OSM-SMI-27-V5, OSM-SMI-27-V6, OSM-SMI-27-U1, OSM-SMI-27-U2, OSM-SMI-27-U3, OSM-SMI-27-U4, OSM-SMI-27-T1, OSM-SMI-27-T2, and/or OSM-SMI-27-T3;
- and a pharmaceutically acceptable carrier.
A small molecule antagonist to oncostatin M (OSM), comprising OSM-SMI-8A, OSM-SMI-8B, OSM-SMI-8C, OSM-SMI-8D, OSM-SMI-8E, OSM-SMI-8F, OSM-SMI-8G, OSM-SMI-8H, OSM-SMI-8I, OSM-SMI-8J, OSM-SMI-8N1, OSM-SMI-10A, OSM-SMI-10B, OSM-SMI-10B-2, OSM-SMI-10B-3, OSM-SMI-10B-4, OSM-SMI-10B-5, OSM-SMI-10B-6, OSM-SMI-10B-7, OSM-SMI-10B-8, OSM-SMI-10B-9, OSM-SMI-10B-10, OSM-SMI-10B-11, OSM-SMI-10B-12, OSM-SMI-10B-13, OSM-SMI-10B-14, OSM-SMI-10B-15, OSM-SMI-10B-16, OSM-SMI-10B-17, OSM-SMI-10B-18, OSM-SMI-10B-19, OSM-SMI-10B-20, OSM-SMI-10B-21, OSM-SMI-10B-22, OSM-SMI-10B-23, OSM-SMI-10B-24, OSM-SMI-10B-25, OSM-SMI-10B-26, OSM-SMI-10B-27, OSM-SMI-10B-28, OSM-SMI-10B-29, OSM-SMI-10B-30, OSM-SMI-10B-31, OSM-SMI-10B-32, OSM-SMI-10B-33, OSM-SMI-10B-34, OSM-SMI-10B-35, OSM-SMI-10B-36, OSM-SMI-10B-37, OSM-SMI-10C, OSM-SMI-10D, OSM-SMI-10E, OSM-SMI-10F, OSM-SMI-10G, OSM-SMI-10H, OSM-SMI-10I, OSM-SMI-10J, OSM-SMI-10K, OSM-SMI-10L, OSM-SMI-10M, OSM-SMI-10N, OSM-SMI-10O, OSM-SMI-10P, OSM-SMI-10Q, OSM-SMI-10R, OSM-SMI-10S, OSM-SMI-23, OSM-SMI-23A, OSM-SMI-23B, OSM-SMI-23C, OSM-SMI-23D, OSM-SMI-23E, OSM-SMI-23F, OSM-SMI-23G, OSM-SMI-23H, OSM-SMI-23I, OSM-SMI-23J, OSM-SMI-23K, OSM-SMI-23L, OSM-SMI-23M, OSM-SMI-23N, OSM-SMI-23O, OSM-SMI-23P, OSM-SMI-23R, OSM-SMI-26, OSM-SMI-26A, OSM-SMI-26B, OSM-SMI-26C, OSM-SMI-26D, OSM-SMI-26E, OSM-SMI-26F, OSM-SMI-26G, OSM-SMI-26H, OSM-SMI-26I, OSM-SMI-26J, OSM-SMI-26K, OSM-SMI-26L, OSM-SMI-26M, OSM-SMI-26N, OSM-SMI-26O, OSM-SMI-26P, OSM-SMI-26Q, OSM-SMI-27, OSM-SMI-27-A1, OSM-SMI-27-A2, OSM-SMI-27-A3, OSM-SMI-27-A4, OSM-SMI-27-A5, OSM-SMI-27-A6, OSM-SMI-27-A7, OSM-SMI-27-A8, OSM-SMI-27-A9, OSM-SMI-27-A10, OSM-SMI-27-A11, OSM-SMI-27-B0, OSM-SMI-27-B1, OSM-SMI-27-B2, OSM-SMI-27-B3, OSM-SMI-27-B4, OSM-SMI-27-B5, OSM-SMI-27-B6, OSM-SMI-27-B7, OSM-SMI-27-B8, OSM-SMI-27-B9, OSM-SMI-27-B10, OSM-SMI-27-B11, OSM-SMI-27-C0, OSM-SMI-27-C1, OSM-SMI-27-C2, OSM-SMI-27-C3, OSM-SMI-27-C4, OSM-SMI-27-C5, OSM-SMI-27-C6, OSM-SMI-27-C7, OSM-SMI-27-C8, OSM-SMI-27-C9, OSM-SMI-27-C10, OSM-SMI-27-C11, OSM-SMI-27-Z1, OSM-SMI-27-Y1, OSM-SMI-27-Y2, OSM-SMI-27-X1, OSM-SMI-27-X2, OSM-SMI-27-X3, OSM-SMI-27-X4, OSM-SMI-27-W1, OSM-SMI-27-W2, OSM-SMI-27-W3, OSM-SMI-27-W4, OSM-SMI-27-W5, OSM-SMI-27-W6, OSM-SMI-27-V1, OSM-SMI-27-V2, OSM-SMI-27-V3, OSM-SMI-27-V4, OSM-SMI-27-V5, OSM-SMI-27-V6, OSM-SMI-27-U1, OSM-SMI-27-U2, OSM-SMI-27-U3, OSM-SMI-27-U4, OSM-SMI-27-T1, OSM-SMI-27-T2, and/or OSM-SMI-27-T3.
Dependencies are inferred from the claim text.