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US 11,633,454 B2Granted
Compositions and methods for treating metabolic diseases
AssigneeShanghai Hep Pharmaceutical Co., Ltd.
InventorHongli Liu
Life of this patent
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Abstract
The disclosure provides compositions and methods of treating a metabolic disease, such as, e.g., diabetes and hyperlipidemia, in a subject, by administering to the subject a therapeutically effective amount of a polypeptide derived from hepatitis B virus or a pharmaceutical composition comprising the polypeptide.
Claims19
A method of regulating a serum lipid level and/or a blood glucose level in a subject in need thereof, comprising
- administering to the subject a therapeutically effective amount of a linear polypeptide or a pharmaceutical composition comprising the linear polypeptide to produce a serum concentration of the administered polypeptide at a concentration above a concentration threshold of 93 nmol/L to inhibit Na+-taurocholate cotransporting polypeptide (NTCP)-mediated bile acid uptake in the subject, thereby lowering the serum lipid level and/or the blood glucose level, and/or
- administering to the subject a therapeutically effective amount of the linear polypeptide or a pharmaceutical composition comprising the linear polypeptide to produce a serum concentration of the administered polypeptide at or below the concentration threshold of 93 nmol/L to enhance NTCP-mediated bile acid uptake in the subject, thereby increasing the serum lipid level and/or the blood glucose level,
- and
- wherein the linear polypeptide comprises an amino acid sequence derived from Hepatitis B virus (HBV), and wherein the amino acid sequence derived from HBV is selected from SEQ ID NOs:
- 21-40.
2 more elements
Dependencies are inferred from the claim text.