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US 11,633,422 B2Granted
Methods and compositions for attenuating anti-viral transfer vector immune responses
AssigneeSelecta Biosciences, Inc.
InventorTakashi Kei Kishimoto
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Abstract
Provided herein are methods and related compositions for administering viral transfer vectors and antigen-presenting cell targeted immunosuppressants.
Claims12
A method comprising:
- establishing an anti-viral transfer vector attenuated response in a subject by repeated, concomitant administration of an antigen-presenting cell targeted immunosuppressant and viral transfer vector to the subject,
- wherein the subject does not have pre-existing immunity against the viral transfer vector;
- and wherein the viral transfer vector is an adenoviral or adeno-associated viral transfer vector.
A method comprising:
- attenuating an anti-viral transfer vector response, wherein the anti-viral transfer vector response is a T cell response, by first administering to a subject a viral transfer vector without an antigen-presenting cell targeted immunosuppressant,
- subsequently concomitantly administering the viral transfer vector and an antigen-presenting cell targeted immunosuppressant to the subject;
- and wherein the viral transfer vector is an adenoviral or adeno-associated viral transfer vector, and
- administering one or more repeat doses of the viral transfer vector subsequent to the concomitant administration of the viral transfer vector and the antigen-presenting cell targeted immunosuppressant to the subject.
1 more element
A method comprising:
- repeatedly, concomitantly administering to a subject an antigen-presenting cell targeted immunosuppressant and viral transfer vector, and
- selecting one or more doses of the viral transfer vector to be less than the dose of the viral transfer vector that would be selected for the subject if the subject were expected to develop anti-viral transfer vector immune responses due to the repeated administration of the viral transfer vector;
- and wherein the viral transfer vector is an adenoviral or adeno-associated viral transfer vector.
Dependencies are inferred from the claim text.