Nicotinoyl riboside compositions and methods of use
AssigneeCornell University
InventorsAnthony A. Sauve, Tianle Yang Redanz
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Abstract
The invention relates to compositions of nicotinoyl ribosides and nicotinamide riboside derivatives and their methods of use. In some embodiments, the invention relates to methods of making nicotinoyl ribosides. In some embodiments, the invention relates to pharmaceutical compositions and nutritional supplements containing a nicotinoyl riboside. In further embodiments, the invention relates to methods of using nicotinoyl ribosides and nicotinamide riboside derivatives that promote the increase of intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells and tissues for improving cell and tissue survival.
Claims20
A method for increasing intracellular levels of nicotinamide adenine dinucleotide (NAD+) in cells, the method comprising administering to the cells a therapeutically effective amount of a compound of formula (I)
- and salt complexes thereof, wherein R is selected from the group consisting of alkylamino, substituted alkylamino, dialkylamino, substituted dialkylamino, alkyloxy, substituted alkyloxy, aryloxy, substituted aryloxy, hydroxylamino, substituted hydroxylamino, O-alkyloxyamino, substituted O-alkyloxyamino, aminooxy, substituted aminooxy, N-alkylaminooxy, substituted N-alkylaminooxy, hydrazino, substituted hydrazino, alkylhydrazino, and substituted alkylhydrazino,
- wherein the administering increases the intracellular levels of NAD+ in the cells.
Dependencies are inferred from the claim text.