Treatment of skin disorders with compositions comprising an EGFR inhibitor

A method of treatment or alleviation of psoriasis by topical administration to a subject in need thereof of a composition comprising:

• (i) a therapeutically effective amount of erlotinib, or a pharmaceutically acceptable salt thereof, in a concentration of from about 3% to about 5% w/w or from about 5% to about 10% w/w;
• and
• (ii) at least one additional active agent selected from the first active agent group consisting of a corticosteroid, calcipotriene, tapinarof, a Janus kinase inhibitor (JAK inhibitor), a phosphodiesterase-4 inhibitor (PDE4 inhibitor), and combinations thereof, in a concentration of from about 0.01% to about 1%, from about 1% to about 3%, or from about 3% to about 5% w/w.

A method of treatment or alleviation of psoriasis by topical administration to a subject in need thereof of a composition comprising:

• (i) a therapeutically effective amount of erlotinib, or a pharmaceutically acceptable salt thereof, in a concentration of from about 3% to about 5% w/w or from about 5% to about 10% w/w;
• and
• (ii) at least one additional active agent selected from the second active agent group consisting of menadione, ketoconazole, dapsone, cevimeline, spironolactone, tretinoin, pimecrolimus, a tetracycline, a sunscreen, doxycycline, epidermal growth factor (EGF), lycopene, threolone, synthomycine, erythromycin, Vitamin K3 and combinations thereof, in a concentration of from about 0.01% to about 1%, from about 1% to about 3%, from about 3% to about 5% w/w.

The method of 2, wherein said composition is a topical composition comprising from about 3% w/w to about 5% w/w or from about 5% w/w to about 10% w/w erlotinib or erlotinib hydrochloride and from about 10% to about 98% w/w at least one penetration enhancer.

The method of 4, wherein said composition is a topical composition comprising from about 3% w/w to about 5% w/w or from about 5% w/w to about 10% w/w erlotinib or erlotinib hydrochloride and from about 10% to about 98% w/w at least one penetration enhancer.

The method of 6, wherein said composition is a topical composition comprising from about 3% w/w to about 5% w/w or from about 5% w/w to about 10% w/w erlotinib or erlotinib hydrochloride and from about 10% to about 98% w/w at least one penetration enhancer.