Substituted alkynylene compounds as anticancer agents

A compound of formula (I)

• or a pharmaceutically acceptable salt or a stereoisomer thereof;
• wherein,
• A represents aryl or heteroaryl;
• X represents N—Ry or absent;
• Y represents O, S or NCN;
• B represents aryl, cycloalkyl or heterocycloalkyl;
• wherein the aryl, cycloalkyl or heterocycloalkyl are optionally substituted with one or more groups selected from alkyl, halo and oxo;
• R1 represents unsubstituted alkyl;
• R2 represents hydrogen or unsubstituted alkyl;
• or R1 and R2 together with the carbon atoms to which they are attached form 3- to 5-membered cycloalkyl ring;
• R3 represents —C(O)Ra, —S(O)2Ra, —NHS(O)2Ra, —NRbC(O)Ra, ═NORa, heteroaryl, heterocycloalkyl or (heterocycloalkyl)alkyl-;
• wherein the heteroaryl and heterocycloalkyl are optionally substituted with one or more groups selected from alkyl, halo, oxo and —C(O)Rx;
• R4 represents alkyl, halo, haloalkyl, cyano, alkoxy, aryloxy, hydroxyalkyl, acetylene, acyl, hydroxy, cycloalkyl or —N(Rx)2;
• wherein the alkoxy is unsubstituted or substituted with unsubstituted phenyl, and the cycloalkyl is optionally substituted with alkyl;
• Ra represents alkyl, alkenyl, haloalkyl, cycloalkyl or heterocycloalkyl;
• wherein the alkyl, alkenyl, haloalkyl, cycloalkyl and heterocycloalkyl are optionally substituted with one or more groups selected from alkyl, halo, aryl, cycloalkyl, haloalkyl, amino, amido, alkylamino, aminoalkyl, hydroxyl, cyano, alkoxy, alkoxyaryl, aryloxy, hydroxyalkyl, carboxylic acid, ester, thioester, oxo(═O) and —C(O)Rx;
• Rx represents hydrogen, alkyl, alkenyl, acyl or —C(O)-cycloalkyl;
• Ry represents hydrogen or alkyl;
• Rb represents hydrogen, alkyl or alkenyl;
• ‘m’ represents 0, 1, 2 or 3.