Use of morphinan derivative for therapeutic treatment of opioid delta receptor agonist-related disease
AssigneeNippon Chemiphar Co., Ltd.
InventorsHiroshi Nagase, Hideaki Fujii, Akiyoshi Saitoh, Eriko Nakata, Masaaki Hirose, Isao Ooi, Kohei Hayashida
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Abstract
The present invention relates to a pharmaceutical composition comprising a morphinan derivative that exhibits an opioid δ receptor agonist activity. By administering the pharmaceutical composition provided by the present invention, opioid δ receptor-related diseases (for example, headache) can be treated or prevented.
Claims14
A method for therapeutic treatment of fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of a compound selected from the group consisting of:
- 2-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridine 1-oxide;
- 3-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)-2(1H)-one;
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridin-2(1H)-one;
- 5-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)-1-methylpyridin-2(1H)-one;
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)-1-methylpyridin-2(1H)-one;
- and
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridazin-3(2H)-one;
- a tautomer or stereoisomer of the compound, or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 2-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridine 1-oxide
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 3-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridin-2(1H)-one
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridin-2(1H)-one
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of a fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 5-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)-1-methylpyridin-2(1H)-one
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of a fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)-1-methylpyridin-2(1H)-one
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
A method for therapeutic treatment of fibromyalgia-associated anxiety or depression in a mammalian subject in need thereof, which comprises administering to the subject an effective amount of
- 6-((1S,3aR,5aS,6R,11bR,11cS)-14-(cyclopropylmethyl)-10-hydroxy-2,3,3a,4,5,6,7,11c-octahydro-1H-6,11b- (epiminoethano)-1,5a-methanonaphtho[1,2-e]indole-3-carbonyl)pyridazin-3(2H)-one
- or a pharmaceutically acceptable salt thereof, or a solvate thereof.
Dependencies are inferred from the claim text.