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US 11,633,379 B2Granted
Methods of inhibiting PCSK9
AssigneesTrustees of Dartmouth College, Oregon Health & Science University
InventorsJimmy Wu, Sergio Fazio, Hagai Tavori
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Abstract
Provided herein are methods for inhibiting PCSK9, reducing PCSK9 levels, and for treating or preventing related conditions and disorders, in a subject, which includes administering to a subject an effective amount of a compound which includes derivatized cycloalkyl[b]indoles, e.g., cyclopenta-, cyclohexa- and cyclohepta[b]indoles.
Claims8
A method for reducing the PCSK9 level in a subject, the method comprising administering to the subject an effective amount of a compound selected from a group consisting of:
- or a pharmaceutically acceptable stereoisomer, isotope, solvate or salt thereof, wherein the subject has a condition associated with an elevated level of PCSK9.
Dependencies are inferred from the claim text.