Methods and compositions for delivering mycophenolic acid active agents to non-human mammals

A method for delivering a sodium mycophenolate composition to a dog, comprising delivering a plurality of modified-release compositions to a lower gastrointestinal tract of the dog via oral administration, wherein the modified-release compositions comprise:

• i. a core having a diameter from about 0.5 mm to about 3 mm;
• ii. a sodium mycophenolate layer disposed over at least a portion of the core;
• iii. a seal coat disposed over the sodium mycophenolate layer;
• iv. a modified-release layer disposed over the seal coat layer;
• and
• v. a protective layer disposed over the modified-release layer,
• wherein the modified-release layer comprises ethyl cellulose from about 15 wt % to about 35 wt % of the composition, the protective layer comprises a methacrylate-based polymer from about 8 wt % to about 15 wt % of the composition and does not dissolve at a pH below 6.0, the sodium mycophenolate is from about 20 wt % to about 90 wt % of the composition, and the sodium mycophenolate is released in the dog according to the following schedule:
• Hours Following
• % Sodium
• Administration
• Mycophenolate Released
• 0.5
• about 0.0 to about 1.0
• 2
• about 3.0 to about 10.0
• 2.5
• about 10.0 to about 30.0
• 3
• about 15.0 to about 40.0
• 4
• about 25.0 to about 55.0
• 6
• about 40.0 to about 75.0
• 7
• about 50.0 to about 80.0
• 10
• about 60.0 to about 90.0
• 14
• about 70.0 to about 100.