Compositions and methods for treating epilepsy, seizures and other conditions

A direct dosing device consisting of a liquid pharmaceutical composition, wherein the liquid pharmaceutical composition consists of:

• (a) polyethylene glycol 400 in an amount of about 45% w/v to about 55% w/v;
• (b) one or more parabens in an amount of about 1.2% w/v to about 2.5% w/v;
• (c) glycerin in an amount of about 60% to about 65% w/v;
• (d) topiramate, or a pharmaceutically acceptable addition salt thereof, in an amount of about 25 mg/ml;
• (e) one or more sweeteners in an amount of about 0.5% w/v to about 2% w/v;
• and
• (f) optionally, a flavor component comprising one or more flavor compounds, the flavor component being in an amount of about 0.1% w/v to about 0.5% w/v;
• wherein:
• the total amount of water present in the composition is 0.35% w/w or less;
• wherein the direct dosing device is a measuring device with graduations, and wherein the direct dosing device is selected from a group consisting of a syringe, a dosing cup, an ampoule, a vial, a spoon, a dropper, and a pipette;
• the liquid pharmaceutical composition does not contain any added water, aqueous acid or base;
• and
• the liquid pharmaceutical composition is a liquid for oral administration.