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US 11,633,371 B2Granted
Deuterated forms of acetaminophen and uses thereof
AssigneeLennham Pharmaceuticals, Inc.
InventorBradford C. Sippy
Life of this patent
Estimating the term…
Abstract
The present disclosure provides compositions comprising deuterated forms of acetaminophen. When administered to human subjects, such compositions form less of the toxic metabolite NAPQI, and therefore are useful in methods of treating various diseases and conditions with a reduced risk of liver injury or other side effects associated with non-deuterated forms of acetaminophen.
Claims28
A method for treating pain or fever in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising an effective amount of compound (In-H):
- or a pharmaceutically acceptable salt thereof;
- wherein the method reduces formation of N-acetyl-p-benzoquinone imine (NAPQI) when compared to the administration of the same or an equivalent amount of acetaminophen in a non-deuterated form.
Dependencies are inferred from the claim text.