Use of scavengers of reactive gamma-ketoaldehydes to extend cell lifespan and healthspan

A method for slowing the progression of cell death in a subject diagnosed with age-related oxidant injury, comprising:

• measuring an isoprostane level in said subject to determine the need for sirtuin modulation;
• and
• administering to said subject an effective sirtuin potentiating amount of a compound selected from the formula:
• wherein:
• R is CH, C—CH3, or C—CH2—CH3;
• R2 is independently H, substituted or unsubstituted alkyl;
• R3 is H, halogen, alkoxy, hydroxyl, nitro;
• R4 is H, substituted or unsubstituted alkyl, carboxyl;
• and pharmaceutically acceptable salts thereof.