Diclofenac and hyaluronic acid combination treatment for oral leukpoplakia

A method of treating a patient with oral leukoplakia or at risk of developing oral leukoplakia, the method comprising:

• administering a therapeutically effective amount of an oral gel composition comprising a nonsteroidal anti-inflammatory drug (NSAID) or a pharmaceutically acceptable salt thereof, hyaluronic acid or a pharmaceutically acceptable salt thereof, a gelling agent or thickener, and a flavoring agent and/or sweetener to a mucosal tissue or an affected portion thereof;
• and
• inserting, in a mouth of the patient, a device comprising:
• an oral retention portion that is suitably shaped to be retained in an oral cavity for a predetermined treatment period, an upper bite flange and a lower bite flange extending from an interior surface of the oral retention portion forming a bite wedge along each end defined by oral retention portion, and a covering portion that extends from the retention portion, the covering portion has at least one surface that contacts the mucosal tissue being treated with the oral gel composition therapeutic agent.