Hypotonic microbicidal formulations and methods of use
AssigneeThe Johns Hopkins University
InventorsKatharina Maisel, Craig W. Hendrix, Laura Ensign, Edward Fuchs, Richard Cone, Justin Hanes
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Abstract
Hypotonic microbicidal compositions including an antimicrobial, such as an antiviral compound, and a pharmaceutically acceptable carrier in a solution formulation having hypotonic osmolarity have been developed for administration rectally to the gastrointestinal mucosa. In a preferred embodiment for use in preventing or decreasing HIV infection, the microbicidal is tenofovir, or a prodrug or derivative thereof. The formulations may include additional agents such as surfactants to enhance cleansing, buffers, or preservatives. Polymers may be included for osmolarity as well as comfort.
Claims17
A method for administration of a therapeutic, prophylactic, or diagnostic agent to a mucosal or epithelial surface comprising administering to a mucosal or epithelial surface in need thereof an effective amount of a composition, comprising a therapeutic, prophylactic, or diagnostic agent as a free drug, and one or more pharmaceutically acceptable carriers suitable for administration at the mucosal or epithelial surface,
- wherein the composition has an effective osmolarity between 20 and 290 mOsm for tissue uptake at the mucosal or epithelial surface for a period of between about 1 hour and seven days following administration.
Dependencies are inferred from the claim text.