Positioning devices, methods, and systems

A system for obtaining a tissue biopsy from a body, the system comprising:

• a tube including a distal end with a first tissue penetrating feature and one or more lumens extending through the tube;
• a shaft movably positioned in a first lumen of the one or more lumens extending through the tube, wherein a distal end of the shaft includes a second tissue penetrating feature configured to penetrate tissue while extended out of the first lumen;
• a transducer coupled to the shaft, the transducer being configured to generate a wave energy in response to a first transmission signal, receive a plurality of reflected portions of the wave energy, wherein each of the plurality of reflected portions of the wave energy have a corresponding magnitude value, generate a plurality of second signals including a first signal based on the corresponding magnitude value of a first reflected portion of the plurality of reflected portions of the wave energy, receive a second reflected portion of the plurality of portions of the wave energy, and generate the plurality of second signals including a second signal based on the corresponding magnitude value of the second reflected portion of the wave energy;
• and
• one or more processors in communication with the transducer, the one or more processors being configured to:
• generate the first transmission signal,
• receive the plurality of second signals including the first signal and the second signal, wherein the first signal includes the corresponding magnitude value of the first reflected portion of the plurality of reflected portions of the wave energy and the second signal includes the corresponding magnitude value of the second reflected portion of the plurality of reflected portions of the wave energy,
• analyze the corresponding magnitude value of the first reflected portion of the plurality of reflected portions of the wave energy with the corresponding magnitude value of the second reflected portion of the plurality of reflected portions of the wave energy,
• determine the respective difference of each magnitude value to identify a first lung nodule corresponding to the first signal of plurality of second signals and to identify a second lung nodule corresponding to the second signal of the plurality of second signals, and
• output indicia of the first lung nodule as targeted tissue and the second lung nodule as non-targeted tissue.