Nutritional composition for improving cell membranes
AssigneeN.V. Nutricia
InventorsAnniek Lidewij Schipper, Eline Marleen Van Der Beek, Dennis Stanley Acton, Nana Bartke, Stefanie Schoen
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Abstract
An early in life nutritional intervention with a lipid component having both large lipid globules with phospholipids and an increased amount of palmitic acid in the sn-2 position in triglycerides were found to improve the fatty acid composition of cell membranes, in particular brain membranes.
Claims16
A method for improving the fatty acid composition of cell membranes in a human subject, the method comprising administering to the subject a nutritional composition comprising lipid in the form of lipid globules, wherein the lipid comprises
- (i) at least 0.5 wt. % alpha-linolenic acid based on total fatty acids,
- (ii) at least 5 wt. % linoleic acid based on total fatty acids,
- (iii) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 25 wt. % of the palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, and
- (iv) at least 1.5 wt. % phospholipid based on total lipid, wherein a part of the phospholipid is in the coating of the lipid globule,
- wherein the lipid globules have a mode diameter based on volume of at least 1 μm and/or at least 45 vol. % have a diameter of 2-12 μm, wherein the nutritional composition comprises vegetable lipid or is not human milk, and wherein the cell membranes are brain cell membranes or red blood cell membranes.
A method for (i) improving cognitive performance and/or improving cognitive development, (ii) improving behavioural performance and/or improving behavioural development, (iii) improving visual acuity, and/or (iv) improving fine motor skills by improving the fatty acid composition of brain cell membranes in a human subject, the method comprising administering to the subject a nutritional composition comprising lipid in the form of lipid globules, wherein the lipid comprises
- (i) at least 0.5 wt. % alpha-linolenic acid based on total fatty acids,
- (ii) at least 5 wt. % linoleic acid based on total fatty acids,
- (iii) at least 10 wt. % palmitic acid based on total fatty acids, wherein at least 25 wt. % of the palmitic acid, based on total palmitic acid, is located at the sn-2 position of a triglyceride, and
- (iv) at least 1.5 wt. % phospholipid based on total lipid, wherein a part of the phospholipid is in the coating of the lipid globule,
- wherein the lipid globules have a mode diameter based on volume of at least 1 μm and/or at least 45 vol. % have a diameter of 2-12 μm, and wherein the nutritional composition comprises vegetable lipid or is not human milk.
Dependencies are inferred from the claim text.