System and method for controlling physiological noise in functional magnetic resonance imaging

A system for controlling physiologically-induced noise in magnetic resonance imaging (MRI) data, comprising:

• a computer system configured to:
• a) acquire MRI k-space data of a subject with a repetition time that samples physiological motion;
• b) determine global physiological fluctuation parameters by extracting an origin point pixel value in a phase image generated from the acquired k-space data;
• c) extract physiological noise from the k-space data that was physiologically-induced by the subject using the global physiological fluctuation parameters;
• and
• d) remove the physiological noise from the MRI data using statistical modeling.

A method for controlling physiologically-induced noise in functional magnetic resonance imaging (fMRI) data, comprising:

• a) acquiring blood-oxygen-level dependent (BOLD) fMRI k-space data of a subject with a repetition time that samples physiological motion, the BOLD fMRI k-space data including small local BOLD fMRI signals intermixed with physiological noise signals;
• b) determining global physiological fluctuation parameters by extracting an origin point pixel value in phase images generated from the acquired k-space data;
• c) extracting the physiological noise from the k-space data that was physiologically-induced by the subject using the global physiological fluctuation parameters;
• and
• d) removing the physiological noise from the MRI data to recover the small local BOLD fMRI signals using statistical modeling.