Diagnostic test for distinguishing the smoking status of a subject
AssigneePhilip Morris Products S.A.
InventorsFrank Luedicke, Manuel C. Peitsch
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Abstract
There is disclosed herein a device for determining the smoking status of a subject, wherein said device comprises a plurality of different specific binding molecules deposited to a solid phase to detect specifically the presence of two or three tobacco smoke exposure biomarkers in a biological sample, said biomarkers consisting of: (i) cotinine and total 4-(methylnitrosamino)-1-(3-, pyridyl)-1-butanol (NNAL); (ii) cotinine and N-acetyl-S-[2-carboxyethyl]-L-cysteine (CEMA); or (iii) cotinine and NNAL and CEMA.
Claims15
A device for determining the smoking status of a subject and configured to detect the presence of only two or three tobacco smoke exposure biomarkers, wherein said device comprises a plurality of different specific binding agents deposited onto a solid phase to detect the presence of only the two or three tobacco smoke exposure biomarkers in a biological sample, said tobacco smoke exposure biomarkers consisting of:
- (i) cotinine and total 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL);
- or
- (ii) cotinine and N-acetyl-S[2-carboxyethyl]-L-cysteine (CEMA);
- or
- (iii) cotinine and total NNAL and CEMA,
- wherein said device is capable of distinguishing current smokers of conventional cigarettes from those who have switched to a smoke-free alternative in which tobacco is heated rather than combusted or from those who have abstained from smoking and providing an indication of the smoking status of the subject based on the distinction.
Dependencies are inferred from the claim text.